57-55-6|1,2-PropanediolProducts Supply - Chemical intermediates Network

1,2-Propanediol cas no:57-55-6

Synonyms: 1,2-propane-diol;DL-1,2-Propanediol;(RS)-1,2-Propanediol;(+-)-1,2-Propanediol;Trimethyl glycol;Propylene Glycol（PG）;alpha-Propylene glycol;2,3-Propanediol;Propylene glycol (TN);Propylene Glycol USP;Sirlene;1,2-dihydroxypropane;alpha-Propyleneglycol;Propylene glycol (JP14/USP);Isopropylene glycol;2-Hydroxypropanol;Sentry Propylene Glycol;Propane-1,2-diol;(+-)-Propylene glycol;Monopropylene glycol;Methylethyl glycol;Dowfrost;Methylethylene glycol;

Identification

Name1,2-Propanediol
CAS57-55-6
Synonyms1,2-propane-diol;DL-1,2-Propanediol;(RS)-1,2-Propanediol;(+-)-1,2-Propanediol;Trimethyl glycol;Propylene Glycol（PG）;alpha-Propylene glycol;2,3-Propanediol;Propylene glycol (TN);Propylene Glycol USP;Sirlene;1,2-dihydroxypropane;alpha-Propyleneglycol;Propylene glycol (JP14/USP);Isopropylene glycol;2-Hydroxypropanol;Sentry Propylene Glycol;Propane-1,2-diol;(+-)-Propylene glycol;Monopropylene glycol;Methylethyl glycol;Dowfrost;Methylethylene glycol;
EINECS(EC#)200-338-0
Molecular FormulaC₃H₈O₂
Molecular Weight76.09

Chemical Properties

Appearanceclear viscous liquid
refractive indexn20/D 1.432(lit.)
storage tempStore at RT.
Sensitive Hygroscopic

Safety Data

Safety Slightly toxic by ingestion, skin contact, intraperitoneal, intravenous, subcutaneous, and intramuscular routes. Human systemic effects by ingestion: general anesthesia, convulsions, changes in surface EEG. Experimental teratogenic and reproductive effects. An eye and human skin irritant. Mutation data reported. Combustible liquid when exposed to heat or flame; can react with oxidizing materials. Explosive in the form of vapor when exposed to heat or flame. May react with hydrofluoric acid + nitric acid + silver nitrate to form the explosive silver fulminate. To fight fire, use alcohol foam. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Statements: 24/25
S24/25:Avoid contact with skin and eyes.
WGK Germany: 1
RTECS: TY2000000
HS Code: 29053200
HS Code 29053200

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LDLo	intravenous	27gm/kg (27000mg/kg)	VASCULAR: OTHER CHANGES	Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 312, 1937.
child	TDLo	oral	79gm/kg/56W-I (79000mg/kg)	BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pediatrics. Vol. 93, Pg. 515, 1978.
dog	LD50	intravenous	26gm/kg (26000mg/kg)		National Technical Information Service. Vol. PB280-477,
dog	LD50	oral	22gm/kg (22000mg/kg)		Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.
guinea pig	LD50	oral	18350mg/kg (18350mg/kg)		Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
guinea pig	LDLo	subcutaneous	15500mg/kg (15500mg/kg)		National Technical Information Service. Vol. PB280-477,
infant	TDLo	parenteral	10gm/kg/3D-C (10000mg/kg)		Pediatrics. Vol. 72, Pg. 353, 1983.
mouse	LD50	intraperitoneal	9718mg/kg (9718mg/kg)	LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI BLOOD: CHANGES IN SPLEEN	Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.
mouse	LD50	intravenous	6630mg/kg (6630mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
mouse	LD50	oral	22gm/kg (22000mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 89, 1939.
mouse	LD50	subcutaneous	17370mg/kg (17370mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 8, Pg. 46, 1981.
quail	LD50	oral	> 2080mg/kg (2080mg/kg)		Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
rabbit	LD50	intravenous	6500mg/kg (6500mg/kg)		National Technical Information Service. Vol. PB280-477,
rabbit	LD50	oral	18500mg/kg (18500mg/kg)		FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 491, 1974.
rabbit	LD50	skin	20800mg/kg (20800mg/kg)		Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 101, 1974.
rabbit	LDLo	intramuscular	6300mg/kg (6300mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: COMA	Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 109, 1932.
rat	LD50	intramuscular	14gm/kg (14000mg/kg)		Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
rat	LD50	intraperitoneal	6660mg/kg (6660mg/kg)		Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981.
rat	LD50	intravenous	6423mg/kg (6423mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat	LD50	oral	20gm/kg (20000mg/kg)		Toxicology and Applied Pharmacology. Vol. 45, Pg. 362, 1978.
rat	LD50	subcutaneous	22500mg/kg (22500mg/kg)		Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,

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1,2-Propanediol cas no:57-55-6

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