Ethynyl estradiol cas no:57-63-6
Synonyms: 19-Nor-17a-pregna-1,3,5(10)-trien-20-yne-3,17-diol(6CI,7CI,8CI);17-Ethinyl-3,17-estradiol;17-Ethinylestradiol;17-Ethynylestra-1,3,5(10)-triene-3,17b-diol;17a-Ethinyl-3,17-dihydroxy-D1,3,5-estratriene;17a-Ethynylestra-3,17b-diol;17a-Ethynylestradiol;19-Nor-17a-pregna-1,3,5(10)-trien-20-yne-3,17b-diol;Amenoron;Chee-O-Gen;Esteed;Estoral;Estorals;Estradiol, 17-ethynyl-;Ethidol;Ethinoral;Ethynylestradiol;Ethynyloestradiol;Eticyclin;Eticyclol;Follicoral;Ginestrene;Linoral;Lynoral;Microfollin;NSC 10973;Oradiol;Orestralyn;Primogyn C;Progynon C;
NameEthynyl estradiol
CAS57-63-6
Synonyms19-Nor-17a-pregna-1,3,5(10)-trien-20-yne-3,17-diol(6CI,7CI,8CI);17-Ethinyl-3,17-estradiol;17-Ethinylestradiol;17-Ethynylestra-1,3,5(10)-triene-3,17b-diol;17a-Ethinyl-3,17-dihydroxy-D1,3,5-estratriene;17a-Ethynylestra-3,17b-diol;17a-Ethynylestradiol;19-Nor-17a-pregna-1,3,5(10)-trien-20-yne-3,17b-diol;Amenoron;Chee-O-Gen;Esteed;Estoral;Estorals;Estradiol, 17-ethynyl-;Ethidol;Ethinoral;Ethynylestradiol;Ethynyloestradiol;Eticyclin;Eticyclol;Follicoral;Ginestrene;Linoral;Lynoral;Microfollin;NSC 10973;Oradiol;Orestralyn;Primogyn C;Progynon C;
EINECS(EC#)200-342-2
Molecular FormulaC20H24O2
Molecular Weight296.40336
AppearanceOff-White to Light-Yellow Crystalline Powder
refractive index-30 ° (C=0.4, Pyridine)
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Hazard T:Toxic
Risk R45;R22
Safety Hazard Codes: T
Risk Statements: 45-22
R45:May cause cancer
R22:Harmful if swallowed
Safety Statements: 53-36/37/39-45
S53:Avoid exposure - obtain special instruction before use
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible.
WGK Germany: 3
RTECS: RC8925000
Confirmed carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects by ingestion: glandular effects. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
250mg/kg (250mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
KIDNEY, URETER, AND BLADDER: OTHER CHANGES |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990. |
| mouse |
LD50 |
oral |
950mg/kg (950mg/kg) |
|
Drugs in Japan Vol. -, Pg. 222, 1995. |
| mouse |
LD50 |
subcutaneous |
> 3gm/kg (3000mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BLOOD: HEMORRHAGE |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990. |
| rat |
LD50 |
intraperitoneal |
471mg/kg (471mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
KIDNEY, URETER, AND BLADDER: OTHER CHANGES |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990. |
| rat |
LD50 |
oral |
960mg/kg (960mg/kg) |
|
Drugs in Japan Vol. -, Pg. 222, 1995. |
| rat |
LD50 |
subcutaneous |
> 2gm/kg (2000mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BLOOD: HEMORRHAGE |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990. |
| women |
TDLo |
oral |
21mg/kg/21D-I (21mg/kg) |
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
GASTROINTESTINAL: NAUSEA OR VOMITING |
Lancet. Vol. 1, Pg. 1479, 1973. |
