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PHYSOSTIGMINE SALICYLATE (1:1) cas no:57-64-7

Synonyms: Eserinesalicylatesalt;Physostigminesalicylate

Identification
NamePHYSOSTIGMINE SALICYLATE (1:1)
CAS57-64-7
SynonymsEserinesalicylatesalt;Physostigminesalicylate
EINECS(EC#)200-343-8
Molecular FormulaC15H21N3O2•C7H6O3
Molecular Weight275.34614
Chemical Properties
AppearanceColourless crystals; odourless.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Safety Data

Hazard T+: Very toxic;
Risk R26/28
Safety

Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects: arrhythmias, nausea or vomiting. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also PHYSOSTIGMINE.
Hazard CodesVeryT+
Risk Statements 26/28
R26/28:Very toxic by inhalation and if swallowed.
Safety Statements 25-45 
S25:Avoid contact with eyes. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 1544 6.1/PG 1
WGK Germany 3
RTECS TJ2450000
HazardClass 6.1(a)
PackingGroup II


Toxicity
1.    

ivn-man TDLo:14 µg/kg:CVS,GIT

    JCLPDE    Journal of Clinical Psychiatry. 46 (1985),446.
2.    

scu-rat LD50:2 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 25 (1973),569.
3.    

ims-rat LD50:1280 µg/kg

    DCTODJ    Drug and Chemical Toxicology. 7 (1984),507.
4.    

orl-mus LD50:2500 µg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 81 (1950),726.
5.    

ipr-mus LD50:640 µg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 28 (1974),227.
6.    

scu-mus LD50:800 µg/kg

    JPPMAB    Journal of Pharmacy and Pharmacology. 34 (1982),603.
7.    

ivn-mus LD50:310 µg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 20 (1971),474.
8.    

scu-dog LDLo:1200 µg/kg

    NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB158-508 .
9.    

scu-cat LDLo:800 µg/kg

    NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB158-508 .
10.    

scu

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UkrOrgSynthesis Ltd.
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Boc Sciences
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Address: 45-16 Ramsey Road, Shirley, NY 11967, USA

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