Benzenesulfonamide,4-amino-N-(4,6-dimethyl-2-pyrimidinyl)- cas no:57-68-1
Synonyms: Sulfanilamide,N1-(4,6-dimethyl-2-pyrimidinyl)- (8CI);2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine;2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine;2-Sulfanilamido-4,6-dimethylpyrimidine;4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide;Azolmetazin;BN 2409;Calfspan;Calfspan Tablets;Diazil;Dimidin R;Kelametazine;Mermeth;N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide;N1-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide;NSC 67457;NSC 683529;Neasina;Neazina;Panazin;Pirmazin;Spanbolet;Sulfadimerazine;Sulfadimesin;Sulfadimethyldiazine;Sulfadimethylpyrimidine;Sulfadimezine;Sulfamethazine;Sulfamethiazine;Sulphadimethylpyrimidine;Sulphadimidine;Sulphamezathine;Sulphamidine;Sulphodimezine;Sustain III;Vertolan;
NameBenzenesulfonamide,4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-
CAS57-68-1
SynonymsSulfanilamide,N1-(4,6-dimethyl-2-pyrimidinyl)- (8CI);2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine;2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine;2-Sulfanilamido-4,6-dimethylpyrimidine;4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide;Azolmetazin;BN 2409;Calfspan;Calfspan Tablets;Diazil;Dimidin R;Kelametazine;Mermeth;N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide;N1-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide;NSC 67457;NSC 683529;Neasina;Neazina;Panazin;Pirmazin;Spanbolet;Sulfadimerazine;Sulfadimesin;Sulfadimethyldiazine;Sulfadimethylpyrimidine;Sulfadimezine;Sulfamethazine;Sulfamethiazine;Sulphadimethylpyrimidine;Sulphadimidine;Sulphamezathine;Sulphamidine;Sulphodimezine;Sustain III;Vertolan;
EINECS(EC#)200-346-4
Molecular FormulaC12H14N4O2S
Molecular Weight278.32
Appearancewhite crystalline powder
storage temp2-8°C
Hazard UN
NO.
Risk R36/37/38
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WO9275000
- CHEMICAL NAME :
- Sulfanilamide, N(sup 1)-(4,6-dimethyl-2-pyrimidinyl)-
- CAS REGISTRY NUMBER :
- 57-68-1
- BEILSTEIN REFERENCE NO. :
- 0261304
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C12-H14-N4-O2-S
- MOLECULAR WEIGHT :
- 278.36
- WISWESSER LINE NOTATION :
- T6N CNJ BMSWR DZ& D1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41,
1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:
27,141,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,392,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1060 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
1001, 00-068 Warsaw 1, Poland) V.10- 1962- Volume(issue)/page/year:
16,804,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1440 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41,
1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:
27,141,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1776 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
1956-59 Volume(issue)/page/year: 5,163,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2450 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65.
For publisher information, see PJPPAA. Volume(issue)/page/year: 11,149,1959
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 52560 mg/kg/2Y-C
- TOXIC EFFECTS :
- Endocrine - changes in thyroid weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 22,175,1987
** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 104 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - thyroid tumors
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
28,157,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5000 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumor types after systemic administration not seen
spontaneously
- REFERENCE :
- ACRAAX Acta Radiologica. (Stockholm, Sweden) V.1-58, 1921-62. For
publisher information, see ACRDA8. Volume(issue)/page/year: 37,258,1952
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 419 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - thyroid tumors
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
27,455,1989
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 6850 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB83-151035
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 8650 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB83-151035
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 46200 mg/kg
- SEX/DURATION :
- male 6 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 81,259,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 25200 mg/kg
- SEX/DURATION :
- female 6-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB85-105690
*** REVIEWS ***
TOXICOLOGY REVIEW
DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand
Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981-
Volume(issue)/page/year: 2(2),5,1982
TOXICOLOGY REVIEW
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
13,747,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83543
No. of Facilities: 1105 (estimated)
No. of Industries: 6
No. of Occupations: 12
No. of Employees: 6918 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83543
No. of Facilities: 1303 (estimated)
No. of Industries: 4
No. of Occupations: 22
No. of Employees: 17376 (estimated)
No. of Female Employees: 2625 (estimated)
