57-92-1|StreptomycinProducts Supply - Chemical intermediates Network

Streptomycin cas no:57-92-1

Synonyms: Streptomycin (8CI);2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-a-glucopyranosyl)-3-formylpentofuranoside;Agrept;Agrimycin;NSC 14083;Neodiestreptopab;Streptomycin A;

Identification

NameStreptomycin
CAS57-92-1
SynonymsStreptomycin (8CI);2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-a-glucopyranosyl)-3-formylpentofuranoside;Agrept;Agrimycin;NSC 14083;Neodiestreptopab;Streptomycin A;
EINECS(EC#)200-355-3
Molecular FormulaC₂₁H₃₉N₇O₁₂
Molecular Weight581.57

Chemical Properties

AppearanceCrystalline powder
storage temp2-8°C

Safety Data

Hazard Damage to nerves and kidneys may result from ingestion. Use restricted by FDA.
Safety

Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human systemic effects by ingestion and intraperitoneal routes: change in vestibular functions, blood pressure decrease, eosinophilia, respiratory depression, and pulmonary changes. Human reproductive and teratogenic effects by unspecified routes: developmental abnormalities of the eye and ear and effects on newborn including postnatal measures or effects. Toxic to kidneys and central nervous system. Has been implicated in aplastic anemia. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	150mg/kg (150mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978.
cat	LDLo	oral	2gm/kg (2000mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978.
cat	LDLo	subcutaneous	600mg/kg (600mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978.
dog	LDLo	subcutaneous	300mg/kg (300mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978.
guinea pig	LDLo	subcutaneous	600mg/kg (600mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978.
human	TDLo	intraperitoneal	143mg/kg (143mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	British Medical Journal. Vol. 1, Pg. 556, 1961.
human	TDLo	oral	400mg/kg/28D- (400mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGES IN VESTIBULAR FUNCTIONS: EAR	Revue Medicale de la Suisse Romande. Vol. 73, Pg. 854, 1953.
human	TDLo	parenteral	28mg/kg/D (28mg/kg)	BLOOD: EOSINOPHILIA	Revue Medicale de la Suisse Romande. Vol. 73, Pg. 820, 1953.
monkey	LDLo	subcutaneous	400mg/kg (400mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978.
mouse	LD50	intraperitoneal	525mg/kg (525mg/kg)		Strahlentherapie. Vol. 127, Pg. 245, 1965.
mouse	LD50	intravenous	90200ug/kg (90.2mg/kg)		Antibiotiki. Vol. 18, Pg. 249, 1973.
mouse	LD50	oral	500mg/kg (500mg/kg)		Yakkyoku. Pharmacy. Vol. 38, Pg. 1493, 1987.
mouse	LD50	subcutaneous	520mg/kg (520mg/kg)		British Journal of Pharmacology and Chemotherapy. Vol. 15, Pg. 496, 1960.
mouse	LD50	unreported	90mg/kg (90mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955.
rabbit	LDLo	intravenous	175mg/kg (175mg/kg)		Naturwissenschaften. Vol. 43, Pg. 183, 1956.
rabbit	LDLo	subcutaneous	600mg/kg (600mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978.
rat	LD50	oral	9gm/kg (9000mg/kg)		"Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revisionVol. 4, Pg. 35, 1976/1977.
rat	LDLo	intravenous	175mg/kg (175mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978.
rat	LDLo	subcutaneous	600mg/kg (600mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 570, 1978.

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Streptomycin cas no:57-92-1

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