13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium,2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-,(13aR,25aS)- cas no:57-95-4

Name13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium,2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-,(13aR,25aS)-
CAS57-95-4
SynonymsTubocuraranium,7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyl-;Tubocurarine (8CI);(+)-Tubocurarine;13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium,2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-,[13aR-(13aR*,25aS*)]-;Tubocurarin;d-Tubocurarine;
Molecular FormulaC37H41 N2 O6
Molecular Weight624.84

Safety

A deadly poison by subcutaneous, intraperitoneal, intramuscular, and intravenous routes. Human toxicity: Large doses and overdoses may cause respiratory paralysis and hypotension. When heated to decomposition it emits toxic fumes of NO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LD50	intravenous	700ug/kg (0.7mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 122, Pg. 152, 1959.
dog	LD50	intravenous	500ug/kg (0.5mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 172, 1949.
dog	LDLo	intramuscular	250ug/kg (0.25mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 10, Pg. 638, 1958.
mouse	LD50	intraperitoneal	410ug/kg (0.41mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 153, Pg. 308, 1965.
mouse	LD50	intravenous	130ug/kg (0.13mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)	Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 130, 1965.
mouse	LD50	subcutaneous	525ug/kg (0.525mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 85, Pg. 603, 1954.
mouse	LD50	unreported	450ug/kg (0.45mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"	Pharmaceutical Chemistry Journal Vol. 2, Pg. 117, 1968.
rabbit	LD50	intravenous	20ug/kg (0.02mg/kg)		Rendiconti Istituto Superiore di Sanita Vol. 13, Pg. 339, 1950.
rabbit	LD50	subcutaneous	500ug/kg (0.5mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 631, 1948.
rat	LD50	intraperitoneal	220ug/kg (0.22mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES CARDIAC: OTHER CHANGES	Journal of Pharmacology and Experimental Therapeutics. Vol. 92, Pg. 454, 1948.
rat	LDLo	intramuscular	500ug/kg (0.5mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Pharmacy and Pharmacology. Vol. 10, Pg. 638, 1958.