1-Piperazineethanol,4-(2-methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]- cas no:57149-07-2

Name1-Piperazineethanol,4-(2-methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-
CAS57149-07-2
Synonyms3-[4-(2-Methoxyphenyl)piperazinyl]-1-naphthyloxypropan-2-ol;Avishot;Flivas;KT 611;Naftopidil;Naftopil;
Molecular FormulaC₂₄H₂₈N₂O₃
Molecular Weight465.41

Appearancewhite crystalline powder
storage tempStore in original container in a cool dark place.

Hazard UN NO.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TL9336500

CHEMICAL NAME :

1-Pioerazineethanol, 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl) -

CAS REGISTRY NUMBER :

57149-07-2

BEILSTEIN REFERENCE NO. :

0629965

LAST UPDATED :

199806

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C24-H28-N2-O3

MOLECULAR WEIGHT :

392.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

4320 mg/kg

SEX/DURATION :

female 16 day(s) after conception - 21 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 48,7,1994

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1080 mg/kg

SEX/DURATION :

female 16 day(s) after conception - 21 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 48,7,1994

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

15680 mg/kg

SEX/DURATION :

male 9 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 48,17,1994

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1300 mg/kg

SEX/DURATION :

female 7-19 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 48,1,1994