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Home > products > 1-Butanone,4-[4-(2,3-dihydro-2-thioxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-(4-fluorophenyl)-

1-Butanone,4-[4-(2,3-dihydro-2-thioxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-(4-fluorophenyl)- cas no:57648-21-2

Synonyms: DD 3480;Timeperone; Timiperone; Tolopelon

Identification

Name1-Butanone,4-[4-(2,3-dihydro-2-thioxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-(4-fluorophenyl)-
CAS57648-21-2
SynonymsDD 3480;Timeperone; Timiperone; Tolopelon
EINECS(EC#)260-880-9
Molecular FormulaC22H24 F N3 O S
Molecular Weight397.55

Chemical Properties

refractive index1.664
storage tempRefrigerator

Safety Data

Safety

Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Used as a tranquilizer. When heated to decomposition it emits toxic fumes of F⁻, SO_x, and NO_x.

Toxicity

dog	LD50	intravenous	20mg/kg (20mg/kg)	Drugs in Japan Vol. -, Pg. 647, 1990.
dog	LD50	oral	85mg/kg (85mg/kg)	Drugs in Japan Vol. -, Pg. 647, 1990.
mouse	LD50	oral	500mg/kg (500mg/kg)	Journal of Medicinal Chemistry. Vol. 21, Pg. 1116, 1978.
rabbit	LD50	oral	237mg/kg (237mg/kg)	Drugs in Japan Vol. -, Pg. 647, 1990.
rat	LD50	intravenous	> 12100ug/kg (12.1mg/kg)	Drugs in Japan Vol. -, Pg. 647, 1990.
rat	LD50	oral	232mg/kg (232mg/kg)	Japanese Journal of Pharmacology. Vol. 27(Suppl), Pg. 124P, 1977.
rat	LD50	subcutaneous	> 2600mg/kg (2600mg/kg)	Drugs in Japan Vol. -, Pg. 647, 1990.

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