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Domperidone cas no:57808-66-9

Synonyms: 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone;Domperidonum;Motilium;

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Identification
NameDomperidone
CAS57808-66-9
Synonyms5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone;Domperidonum;Motilium;
EINECS(EC#)260-968-7
Molecular FormulaC22 H24 Cl N5 O2
Molecular Weight425.91126
Chemical Properties
Appearancewhite powder
storage tempKeep tightly closed.
Safety Data

Hazard Xn:Harmful
Risk R62;R63
Safety

Poison by intravenous and intraperitoneal routes. Human systemic effects by intravenous and intramuscular routes: eye effects, convulsions, muscle spasms and cardiac arrhythmias. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of Cl? and NOx.
Hazard Codes:?HarmfulXn
Risk Statements: 62-63?
R62: Risk of impaired fertility.?
R63: Possible risk of harm to the unborn child.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.
WGK Germany of Domperidone (CAS NO.57808-66-9): 3?


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 42700ug/kg (42.7mg/kg) BEHAVIORAL: ATAXIA
BEHAVIORAL: ANTIPSYCHOTIC
GASTROINTESTINAL: NAUSEA OR VOMITING		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 244, Pg. 130, 1980.
dog LD50 oral > 160mg/kg (160mg/kg) ? Archives Internationales de Pharmacodynamie et de Therapie. Vol. 244, Pg. 130, 1980.
dog LD50 rectal > 120mg/kg (120mg/kg) ? Yakkyoku. Pharmacy. Vol. 35, Pg. 625, 1984.
dog LD50 subcutaneous > 160mg/kg (160mg/kg) ? Archives Internationales de Pharmacodynamie et de Therapie. Vol. 244, Pg. 130, 1980.
guinea pig LD50 intravenous 42900ug/kg (42.9mg/kg) BEHAVIORAL: ATAXIA
GASTROINTESTINAL: NAUSEA OR VOMITING
BEHAVIORAL: ANTIPSYCHOTIC		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 244, Pg. 130, 1980.
human LDLo intravenous 429ug/kg (0.429mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD British Medical Journal. Vol. 288, Pg. 1728, 1984.
human TDLo intravenous 714ug/kg (0.714mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD British Medical Journal. Vol. 288, Pg. 1728, 1984.
infant TDLo oral 1170ug/kg/1D- (1.17mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Journal of Pediatrics. Vol. 108, Pg. 630, 1986.
man TDLo intramuscular 200ug/kg (0.2mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Lancet. Vol. 2, Pg. 1259, 1980.
man TDLo oral 234mg/kg/39W- (234mg/kg) ENDOCRINE: GYNECOMASTIA Postgraduate Medical Journal. Vol. 67, Pg. 401, 1991.
mouse LD50 intraperitoneal > 8gm/kg (8000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
mouse LD50 intravenous 46500ug/kg (46.5mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
mouse LD50 oral > 8gm/kg (8000mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982.
mouse LD50 subcutaneous > 8gm/kg (8000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
rat LD50 intraperitoneal 61200ug/kg (61.2mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982.
rat LD50 intravenous 41700ug/kg (41.7mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
rat LD50 oral 5243mg/kg (5243mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
rat LD50 rectal > 250mg/kg (250mg/kg) ? Yakkyoku. Pharmacy. Vol. 35, Pg. 625, 1984.
rat LD50 subcutaneous > 8gm/kg (8000mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
women TDLo intravenous 600ug/kg/1D (0.6mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Lancet. Vol. 2, Pg. 385, 1985.
women TDLo intravenous 1mg/kg (1mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) British Medical Journal. Vol. 289, Pg. 1579, 1984.
women TDLo rectal 7200ug/kg/30H (7.2mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Journal of Pediatrics. Vol. 105, Pg. 852, 1984.
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