(7S-cis)-9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxynaphthacene-5,12-dione hydrochloride cas no:57852-57-0
Synonyms: Idarubicin Hydrochloride
Name(7S-cis)-9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxynaphthacene-5,12-dione hydrochloride
CAS57852-57-0
SynonymsIdarubicin Hydrochloride
EINECS(EC#)260-990-7
Molecular FormulaC26H27NO9?HCl
Molecular Weight533.95
storage temp2-8°C
Hazard T+:Verytoxic;
Risk R60;R61;R28;R40
Safety
A poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic vapors of NOx, HCl, and Cl−.
Hazard Codes: 
T+
Xn
Risk Statements: 60-61-28-40
R28: Very toxic if swallowed.
R40: Limited evidence of a carcinogenic effect.
R60: May impair fertility.
R61: May cause harm to the unborn child.
Safety Statements: 53-45-36-22
S22: Do not breathe dust.
S36: Wear suitable protective clothing.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53: Avoid exposure - obtain special instructions before use.
RIDADR: UN2811
RTECS: HB7877000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD |
intravenous |
> 500ug/kg (0.5mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 364, 1995. |
| mouse |
LD50 |
intravenous |
4100ug/kg (4.1mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 364, 1995. |
| mouse |
LD50 |
oral |
13980ug/kg (13.98mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 364, 1995. |
| mouse |
LD50 |
subcutaneous |
4690ug/kg (4.69mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 364, 1995. |
| mouse |
LDLo |
intraperitoneal |
700ug/kg (0.7mg/kg) |
|
Cancer Treatment Reports. Vol. 60, Pg. 829, 1976. |
| rat |
LD50 |
intravenous |
3080ug/kg (3.08mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 364, 1995. |
| rat |
LD50 |
oral |
5430ug/kg (5.43mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 364, 1995. |
| rat |
LD50 |
subcutaneous |
2930ug/kg (2.93mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 364, 1995. |
