5786-21-0|clozapineProducts Supply - Chemical intermediates Network

clozapine cas no:5786-21-0

Synonyms: -

Identification

Nameclozapine
CAS5786-21-0
Synonyms-
EINECS(EC#)227-313-7
Molecular FormulaC18H19ClN4
Molecular Weight326.82326

Chemical Properties

Appearancea yellow, crystalline powder, very slightly soluble in water
refractive index1.681
storage tempKeep tightly closed.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xi:Irritant
Risk R22;R36/37/38
Safety

Hazard Codes:? Harmful Xn, Irritant Xi
Risk Statements: 22-36/37/38?
R22:Harmful if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	4762ug/kg (4.762mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: ANTIPSYCHOTIC	American Journal of Emergency Medicine. Vol. 14, Pg. 462, 1996.
dog	LD50	oral	145mg/kg (145mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Farmaco, Edizione Pratica. Vol. 26, Pg. 585, 1971.
guinea pig	LD50	oral	510mg/kg (510mg/kg)	?	Farmaco, Edizione Pratica. Vol. 26, Pg. 585, 1971.
human	TDLo	oral	5mg/kg/7D-I (5mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 919, 1972.
man	TDLo	oral	4286ug/kg/11D (4.286mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)	Journal of Clinical Pyschopharmacology. Vol. 13, Pg. 155, 1993.
man	TDLo	oral	5357ug/kg/5D- (5.357mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: ANTIPSYCHOTIC CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Journal of Clinical Pyschopharmacology. Vol. 12, Pg. 139, 1992.
man	TDLo	oral	27mg/kg/13D-I (27mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: ATAXIA	Journal of Clinical Psychiatry. Vol. 55, Pg. 38, 1994.
man	TDLo	oral	40mg/kg (40mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Veterinary and Human Toxicology. Vol. 41, Pg. 20, 1999.
man	TDLo	oral	86mg/kg/15D-I (86mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	British Journal of Psychiatry. Vol. 173, Pg. 440, 1998.
man	TDLo	oral	270mg/kg/6W-I (270mg/kg)	LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI BLOOD: AGRANULOCYTOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Annales de Medecine Interne. Vol. 144, Pg. 494, 1993.
man	TDLo	oral	429mg/kg/60D- (429mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	American Journal of Psychiatry. Vol. 152, Pg. 649, 1995.
man	TDLo	oral	429mg/kg (429mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BEHAVIORAL: COMA	Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 325, 2000.
man	TDLo	oral	2211mg/kg/37W (2211mg/kg)	BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	Journal of Clinical Pyschopharmacology. Vol. 15, Pg. 287, 1995.
man	TDLo	oral	3280mg/kg/82W (3280mg/kg)	BLOOD: AGRANULOCYTOSIS	American Journal of Psychiatry. Vol. 153, Pg. 1503, 1996.
mouse	LD50	intraperitoneal	90mg/kg (90mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Farmaco, Edizione Pratica. Vol. 26, Pg. 585, 1971.
mouse	LD50	intravenous	36500ug/kg (36.5mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 667, 1973.
mouse	LD50	oral	150mg/kg (150mg/kg)	?	Journal of Medicinal Chemistry. Vol. 23, Pg. 878, 1980.
mouse	LD50	subcutaneous	194mg/kg (194mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 667, 1973.
rat	LD50	intramuscular	210mg/kg (210mg/kg)	?	Farmaco, Edizione Pratica. Vol. 26, Pg. 585, 1971.
rat	LD50	intravenous	41600ug/kg (41.6mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 667, 1973.
rat	LD50	oral	251mg/kg (251mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 667, 1973.
rat	LD50	subcutaneous	240mg/kg (240mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 667, 1973.
women	TDLo	oral	20mg/kg (20mg/kg)	BEHAVIORAL: COMA BLOOD: LEUKOPENIA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS	Annals of Internal Medicine. Vol. 121, Pg. 722, 1994.
women	TDLo	oral	28mg/kg/2W-I (28mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS	Lancet. Vol. 340, Pg. 251, 1992.
women	TDLo	oral	96mg/kg/48D-I (96mg/kg)	BLOOD: LEUKOPENIA BLOOD: AGRANULOCYTOSIS	Human Psychopharmacology. Vol. 13, Pg. 583, 1998.
women	TDLo	oral	104mg/kg/26D- (104mg/kg)	BLOOD: EOSINOPHILIA	Journal of Clinical Psychiatry. Vol. 59, Pg. 195, 1998.
women	TDLo	oral	168mg/kg/4W-I (168mg/kg)	BLOOD: AGRANULOCYTOSIS	Netherlands Journal of Medicine. Vol. 52, Pg. 26, 1998.
women	TDLo	oral	280mg/kg/5W-I (280mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" BLOOD: EOSINOPHILIA	American Journal of Psychiatry. Vol. 150, Pg. 985, 1993.

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clozapine cas no:5786-21-0

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