4H-Dibenzo[de,g]quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-methyl-, (6aR)- cas no:58-00-4

Name4H-Dibenzo[de,g]quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-methyl-, (6aR)-
CAS58-00-4
Synonyms4H-Dibenzo[de,g]quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-methyl-, (R)-; 6ab-Aporphine-10,11-diol (8CI);(-)-10,11-Dihydroxyaporphine; (-)-Apomorphine; (R)-(-)-Apomorphine; Apokyn;Apomorphin; Apomorphine; Ixense; l-Apomorphine
EINECS(EC#)200-360-0, 206-243-0
Molecular FormulaC17H17 N O2
Molecular Weight303.79 .

Appearancewhite to grayish powder

Hazard UN NO.
Safety

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Central nervous system effects. A powerful emetic. A weak sensitizer and may cause contact dermatitis. When heated to decomposition it emits highly toxic fumes of NO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	rectal	50mg/kg (50mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
dog	LDLo	subcutaneous	50mg/kg (50mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog	LDLo	subcutaneous	300mg/kg (300mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
mouse	LD50	intraperitoneal	160mg/kg (160mg/kg)		Journal of Medicinal Chemistry. Vol. 15, Pg. 348, 1972.
mouse	LD50	intravenous	56mg/kg (56mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03170,
mouse	LD50	oral	> 100mg/kg (100mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS	Farmaco, Edizione Scientifica. Vol. 35, Pg. 951, 1980.
mouse	LDLo	subcutaneous	13mg/kg (13mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
pigeon	LDLo	subcutaneous	200mg/kg (200mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rabbit	LDLo	intravenous	10mg/kg (10mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rabbit	LDLo	subcutaneous	5mg/kg (5mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rat	LDLo	intravenous	40mg/kg (40mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 1003, 1960.