10H-Phenothiazine,2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- cas no:58-38-8
Synonyms: Phenothiazine,2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- (7CI,8CI); 2-Chloro-10-(3-[1-methyl-4-piperazinyl]propyl)phenothiazine;2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine;3-Chloro-10-[3-(1-methyl-4-piperazinyl)propyl]phenothiazine; 6140RP; Bayer A173; Capazine; Chlormeprazine; Chlorperazine; Emelent; Kronocin; Meterazin;Meterazine; N-[g-(4'-Methylpiperazinyl-1')propyl]-3-chlorophenothiazine;NSC 17478; NSC 665801; Nipodal; Proazine; Prochlorpemazine; Prochlorperazin;Prochlorperazine; Prochlorpromazine; RP 6140; SKF 4657; Temetid
Name10H-Phenothiazine,2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-
CAS58-38-8
SynonymsPhenothiazine,2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- (7CI,8CI); 2-Chloro-10-(3-[1-methyl-4-piperazinyl]propyl)phenothiazine;2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine;3-Chloro-10-[3-(1-methyl-4-piperazinyl)propyl]phenothiazine; 6140RP; Bayer A173; Capazine; Chlormeprazine; Chlorperazine; Emelent; Kronocin; Meterazin;Meterazine; N-[g-(4'-Methylpiperazinyl-1')propyl]-3-chlorophenothiazine;NSC 17478; NSC 665801; Nipodal; Proazine; Prochlorpemazine; Prochlorperazin;Prochlorperazine; Prochlorpromazine; RP 6140; SKF 4657; Temetid
EINECS(EC#)200-379-4
Molecular FormulaC20H24 Cl N3 S
Molecular Weight373.98
AppearanceClear, pale yellow, viscous liquid.
storage tempProtect from light. Keep in a tightly closed container in a cool, dry location.
Safety
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: headache, blood pressure elevation. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−.
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orl-hmn TDLo:560 µg/kg/10H-I:CNS,CVS
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NEJMAG New England Journal of Medicine. 312 (1985),1125. |
| 2. |
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orl-rat LD50:1800 mg/kg
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27ZIAQ Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,213. |
| 3. |
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ivn-rat LDLo:20 mg/kg
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AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 120 (1959),450. |
| 4. |
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orl-mus LD50:400 mg/kg
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NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),722. |
| 5. |
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ipr-mus LD50:120 mg/kg
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CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 152 (1958),1371. |
| 6. |
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scu-mus LD50:400 mg/kg
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NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),722. |
| 7. |
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orl-dog LDLo:102 mg/kg
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27ZIAQ Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,213. |
| 8. |
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ivn-dog LDLo:100 mg/kg
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27ZIAQ Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,213. |
| 9. |
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ivn-rbt LDLo:5 mg/kg
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