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1-Piperazineethanol,4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]- cas no:58-39-9

Synonyms: 1-Piperazineethanol,4-[3-(2-chlorophenothiazin-10-yl)propyl]- (8CI);1-(2-Hydroxyethyl)-4-[3-(2-chloro-10-phenothiazinyl)propyl]piperazine;2-Chloro-10-3-[1-(2-hydroxyethyl)-4-piperazinyl] propyl phenothiazine;2-Chloro-10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazine;Chloriprozine;Chlorperphenazine;Decentan;Emesinal;Etaperazin;Etaperazine;Ethaperazine;Fentazin;Fentazin syrup;Fentazine duolets;Mutabom;NSC 150866;PZC;Perfenazine;Perfenil;Perphenan;Perphenazin;Sch 3940;Thilatazin;Tranquisan;Trifaron;Trilafon;Trilifan;Triphenot;g-[4-(b-Hydroxyethyl)piperazin-1-yl]propyl-2-chlorophenothiazine;4-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-piperazineethanol;

Identification
Name1-Piperazineethanol,4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-
CAS58-39-9
Synonyms1-Piperazineethanol,4-[3-(2-chlorophenothiazin-10-yl)propyl]- (8CI);1-(2-Hydroxyethyl)-4-[3-(2-chloro-10-phenothiazinyl)propyl]piperazine;2-Chloro-10-3-[1-(2-hydroxyethyl)-4-piperazinyl] propyl phenothiazine;2-Chloro-10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazine;Chloriprozine;Chlorperphenazine;Decentan;Emesinal;Etaperazin;Etaperazine;Ethaperazine;Fentazin;Fentazin syrup;Fentazine duolets;Mutabom;NSC 150866;PZC;Perfenazine;Perfenil;Perphenan;Perphenazin;Sch 3940;Thilatazin;Tranquisan;Trifaron;Trilafon;Trilifan;Triphenot;g-[4-(b-Hydroxyethyl)piperazin-1-yl]propyl-2-chlorophenothiazine;4-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-piperazineethanol;
EINECS(EC#)200-381-5
Molecular FormulaC21H26ClN3OS
Molecular Weight403.96
Chemical Properties
Appearancewhite yellowish powder
storage temp2-8°C
Safety Data

Hazard 6.1 (Packing Group: III) UN NO.
Risk R22
Safety

Safety Information of Perphenazine (58-39-9):
Hazard Codes: Xn
Risk Statements: 22-43
22: Harmful if swallowed
43: May cause sensitization by skin contact
Safety Statements: 28-36/37/39-45
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
WGK Germany: 3
RTECS: TL7175000
Poison by ingestion, intravenous, subcutaneous, intraperitoneal, and intramuscular routes. Human systemic effects by intramuscular route: muscle spasms. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl.


Toxicity
1.    

cyt-hmn:leu 270 mg/kg

    BMJOAE    British Medical Journal. 3 (1969),634.
2.    

orl-mus TDLo:150 mg/kg (female 10-12D post):TER

    TOIZAG    Toho Igakkai Zasshi. Journal of Medical Society of Toho University. 28 (1981),621.
3.    

ims-hmn TDLo:71,428 ng/kg:CNS

    BMJOAE    British Medical Journal. 3 (1967),867.
4.    

orl-rat LD50:318 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 21 (1972),315.
5.    

ipr-rat LD50:146 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 24 (1974),917.
6.    

ivn-rat LD50:34 mg/kg

    FRPPAO    Farmaco, Edizione Pratica. 26 (1971),585.
7.    

orl-mus LD50:120 mg/kg

    27ZIAQ    Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1965.
8.    

ipr-mus LD50:64 mg/kg

    JPMSAE    Journal of Pharmaceutical Sciences. 59 (1970),976.
9.    

ivn-mus LD50:19 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 11 (1961),932.
10.    

ivn-dog LD50:51 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 10 (1960)

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