10H-Phenothiazine-10-propanamine,N,N-dimethyl- cas no:58-40-2

Name10H-Phenothiazine-10-propanamine,N,N-dimethyl-
CAS58-40-2
SynonymsPhenothiazine,10-[3-(dimethylamino)propyl]- (8CI); 10-[3-(Dimethylamino)propyl]phenothiazine;3276RP; A 145; Ampazine; Berophen; Esparin;N-(3-Dimethylaminopropyl)phenothiazine; NSC 31447; Neo-Hibernex; Prazin;Prazine; Promazine; Protactyl; RP 3276; Romtiazin; Sinophenin; Tomil; Verophen;Wy 1094
EINECS(EC#)200-382-0
Molecular FormulaC17H20 N2 S
Molecular Weight284.45

Safety

Human poison by unspecified route. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	140mg/kg (140mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 69, 1965.
mouse	LD50	intravenous	45mg/kg (45mg/kg)	BEHAVIORAL: SLEEP	Acta Pharmacologica et Toxicologica. Vol. 19, Pg. 87, 1962.
mouse	LD50	oral	401mg/kg (401mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 489, 1958.
mouse	LD50	subcutaneous	110mg/kg (110mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1798, 1974.
rabbit	LD50	intravenous	21mg/kg (21mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959.
rat	LD50	intravenous	14500ug/kg (14.5mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGES IN CIRCULATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 119, Pg. 311, 1959.
rat	LD50	oral	350mg/kg (350mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 507, 1958.
rat	LD50	subcutaneous	192mg/kg (192mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1798, 1974.
rat	LDLo	intraperitoneal	210mg/kg (210mg/kg)		Toxicology and Applied Pharmacology. Vol. 1, Pg. 156, 1959.