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Acetic acid,2-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]- cas no:58-54-8

Synonyms: Aceticacid, [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]- (9CI); Acetic acid,[2,3-dichloro-4-(2-methylenebutyryl)phenoxy]- (8CI);2,3-Dichloro-4-(2-ethyl-1-oxo-2-propenyl)-phenoxyacetic acid; Crinuril;Edecril; Edecrin; Edecrina; Endecril; Etacrynic acid; Etakrinic acid;Ethacrynic acid; Hidromedin; Hydromedin; MK 595; Mingit; NSC 624008; NSC 85791;Otacril; Reomax; Taladren; Uregit;[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid;[2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]acetic acid;[4-(2-Methylenebutyryl)-2,3-dichlorophenoxy]acetic acid

Identification
NameAcetic acid,2-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]-
CAS58-54-8
SynonymsAceticacid, [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]- (9CI); Acetic acid,[2,3-dichloro-4-(2-methylenebutyryl)phenoxy]- (8CI);2,3-Dichloro-4-(2-ethyl-1-oxo-2-propenyl)-phenoxyacetic acid; Crinuril;Edecril; Edecrin; Edecrina; Endecril; Etacrynic acid; Etakrinic acid;Ethacrynic acid; Hidromedin; Hydromedin; MK 595; Mingit; NSC 624008; NSC 85791;Otacril; Reomax; Taladren; Uregit;[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid;[2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]acetic acid;[4-(2-Methylenebutyryl)-2,3-dichlorophenoxy]acetic acid
EINECS(EC#)200-384-1
Molecular FormulaC13H12 Cl2 O4
Molecular Weight303.15
Chemical Properties
AppearanceWhite solid.
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Safety Data

Hazard Xn: Harmful;
Risk R20/21/22;R36/37/38
Safety

Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion and intravenous routes: urine volume increase, impaired hearing, and tinnitus (ringing in the ears). A diuretic. When heated to decomposition it emits toxic fumes of Cl.Safety information of Ethacrynic acid (CAS NO.58-54-8):
Hazard Codes  HarmfulXn
Risk Statements 
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements 
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36 Wear suitable protective clothing
WGK Germany  3
RTECS  AG6600000


Toxicity
1.    

orl-wmn TDLo:4 mg/kg:EAR

    AIMDAP    Archives of Internal Medicine. 117 (1966),715.
2.    

orl-man TDLo:3 mg/kg:EAR,KID

    AIMDAP    Archives of Internal Medicine. 117 (1966),715.
3.    

ivn-wmn TDLo:3 mg/kg:EAR

    AIMDAP    Archives of Internal Medicine. 117 (1966),715.
4.    

orl-rat LD50:1 g/kg

    YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 21 (1979),775.
5.    

ipr-rat LD50:43 mg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 2 (1968),411.
6.    

orl-mus LD50:627 mg/kg

    MEIEDD    Merck Index. 10 (1983),539.
7.    

ivn-mus LD50:176 mg/kg

    MEIEDD    Merck Index. 10 (1983),539.

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