58-55-9|1H-Purine-2,6-dione,3,9-dihydro-1,3-dimethyl-Products Supply

1H-Purine-2,6-dione,3,9-dihydro-1,3-dimethyl- cas no:58-55-9

Synonyms: 1H-Purine-2,6-dione,3,7-dihydro-1,3-dimethyl- (9CI);Theophylline (8CI);1,3-Dimethylxanthine;Accurbron;Aerobin;Aerolate;Afonilm;Apnecut;Armophylline;Asmax;Austyn;Bilordyl;Brochoretard;Bronkodyl;Cetraphylline;Chronophyllin;Diffumal;Duraphyl;Egifilin;Elixophyllin;Etheophyl;Euphylong;LaBID;Lanophyllin;Nuelin;Optiphyllin;Parkophyllin;Physpan;Pro-Vent;PulmiDur;Pulmo-Timelets;Quibron T/SR;Respbid;Respicur;Solosin;SomophyllinCRT;Somophyllin T;Spophyllin retard;Sustaire;Talotren;Telb-DS;Telbans;Telbans Dry Syrup;Teonova;Theo 24;Theo-Dur;Theo-Sav;Theobid;Theobid Duracap;Theoclear;Theodel;Theodrip;Theodur Dry Syrup;Theograd;Theolair;Theona P;Theopek;Theoplus;Theostat;Theotard;Theovent;Throphylline;Unicontin CR;Unilong;Uniphyl;Uniphyllin;Xanthium;Zydus;

Identification

Name1H-Purine-2,6-dione,3,9-dihydro-1,3-dimethyl-
CAS58-55-9
Synonyms1H-Purine-2,6-dione,3,7-dihydro-1,3-dimethyl- (9CI);Theophylline (8CI);1,3-Dimethylxanthine;Accurbron;Aerobin;Aerolate;Afonilm;Apnecut;Armophylline;Asmax;Austyn;Bilordyl;Brochoretard;Bronkodyl;Cetraphylline;Chronophyllin;Diffumal;Duraphyl;Egifilin;Elixophyllin;Etheophyl;Euphylong;LaBID;Lanophyllin;Nuelin;Optiphyllin;Parkophyllin;Physpan;Pro-Vent;PulmiDur;Pulmo-Timelets;Quibron T/SR;Respbid;Respicur;Solosin;SomophyllinCRT;Somophyllin T;Spophyllin retard;Sustaire;Talotren;Telb-DS;Telbans;Telbans Dry Syrup;Teonova;Theo 24;Theo-Dur;Theo-Sav;Theobid;Theobid Duracap;Theoclear;Theodel;Theodrip;Theodur Dry Syrup;Theograd;Theolair;Theona P;Theopek;Theoplus;Theostat;Theotard;Theovent;Throphylline;Unicontin CR;Unilong;Uniphyl;Uniphyllin;Xanthium;Zydus;
EINECS(EC#)200-385-7
Molecular FormulaC₇H₈N₄O₂
Molecular Weight180.16

Chemical Properties

Appearancewhite to off-white crystalline powder
refractive index1.737
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xn:Harmful
Risk R22
Safety

Human poison by ingestion, parenteral, intravenous, and rectal routes. Experimental poison by multiple routes. An experimental teratogen. Human systemic effects: coma, convulsions or effect on seizure threshold, cyanosis, EKG changes, fever and other metabolic effects, heart arrhythmias, heart rate change, hyperglycemia, metabolic acidosis, nausea or vomiting, potassium-level changes, respiratory stimulation, salivary gland changes, somnolence, tremor. Experimental reproductive effects. Human mutation data reported. Used as a diuretic, cardiac stimulant, smooth muscle relaxant, and to treat asthma. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes:?Xn,T,F,Xi
Risk Statements: 22-39/23/24/25-23/24/25-11-36/37/38?
R22:Harmful if swallowed.
R39:Danger of very serious irreversible effects.?
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.?
R11:Highly flammable.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 7-16-36/37-45-36-26?
S7:Keep container tightly closed.?
S16:Keep away from sources of ignition.?
S36/37:Wear suitable protective clothing and gloves.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36:Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 1
RTECS of Theophylline (CAS NO.58-55-9): XH3850000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	intramuscular	50mg/kg (50mg/kg)	BEHAVIORAL: EXCITEMENT CARDIAC: CHANGE IN RATE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Journal of Pediatrics. Vol. 90, Pg. 827, 1977.
child	TDLo	oral	10mg/kg (10mg/kg)	BEHAVIORAL: HEADACHE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP GASTROINTESTINAL: NAUSEA OR VOMITING	Southern Medical Journal. Vol. 78, Pg. 1000, 1985.
guinea pig	LD50	oral	183mg/kg (183mg/kg)	?	United States Patent Document. Vol. #4089959,
guinea pig	LDLo	subcutaneous	170mg/kg (170mg/kg)	?	"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 168, 1959.
human	TDLo	intravenous	10mg/kg/D (10mg/kg)	BEHAVIORAL: TREMOR CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) GASTROINTESTINAL: NAUSEA OR VOMITING	JAMA, Journal of the American Medical Association. Vol. 235, Pg. 1983, 1976.
human	TDLo	oral	5mg/kg (5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 92, 1969.
human	TDLo	rectal	6mg/kg (6mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 92, 1969.
human	TDLo	subcutaneous	3500ug/kg (3.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 92, 1969.
infant	TDLo	oral	348mg/kg/4D-I (348mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN BEHAVIORAL: IRRITABILITY LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Pediatric Pharmacology. Vol. 5, Pg. 209, 1985.
man	LDLo	intravenous	3429ug/kg (3.429mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	JAMA, Journal of the American Medical Association. Vol. 136, Pg. 397, 1948.
man	LDLo	parenteral	12mg/kg (12mg/kg)	?	Deutsches Archiv fuer Klinische Medizin. Vol. 80, Pg. 510, 1904.
man	TDLo	oral	66mg/kg (66mg/kg)	CARDIAC: CHANGE IN RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION GASTROINTESTINAL: NAUSEA OR VOMITING	American Journal of Emergency Medicine. Vol. 11, Pg. 609, 1993.
man	TDLo	oral	66mg/kg (66mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: CONTRACTION (ISOLATED TISSUE) GASTROINTESTINAL: NAUSEA OR VOMITING	Medical Journal of Australia. Vol. 156, Pg. 512, 1992.
man	TDLo	oral	86mg/kg (86mg/kg)	CARDIAC: CHANGE IN RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Annals of Emergency Medicine. Vol. 20, Pg. 1143, 1991.
man	TDLo	oral	129mg/kg (129mg/kg)	ENDOCRINE: HYPERGLYCEMIA	Annals of Internal Medicine. Vol. 104, Pg. 284, 1986.
mouse	LD50	intramuscular	271mg/kg (271mg/kg)	?	Drugs in Japan Vol. 6, Pg. 34, 1982.
mouse	LD50	intraperitoneal	70mg/kg (70mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	British Journal of Pharmacology. Vol. 73, Pg. 887, 1981.
mouse	LD50	intravenous	136mg/kg (136mg/kg)	?	Pharmaceutica Acta Helvetiae. Vol. 48, Pg. 133, 1973.
mouse	LD50	oral	235mg/kg (235mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 45, Pg. 569, 1995.
mouse	LD50	rectal	166mg/kg (166mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Pediatric Research. Vol. 11, Pg. 783, 1977.
mouse	LD50	subcutaneous	138mg/kg (138mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 328, 1953.
mouse	LD50	unreported	400mg/kg (400mg/kg)	?	United States Patent Document. Vol. #4767763,
rabbit	LD50	intravenous	150mg/kg (150mg/kg)	?	Drugs in Japan Vol. 6, Pg. 34, 1982.
rabbit	LD50	oral	350mg/kg (350mg/kg)	?	"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 865, 1986.
rat	LD50	intraperitoneal	150mg/kg (150mg/kg)	?	United States Patent Document. Vol. #4120947,
rat	LD50	oral	225mg/kg (225mg/kg)	?	United States Patent Document. Vol. #4089959,
rat	LD50	unreported	300mg/kg (300mg/kg)	?	United States Patent Document. Vol. #4767763,
rat	LDLo	intravenous	240mg/kg (240mg/kg)	?	"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 259, 1973.
rat	LDLo	subcutaneous	325mg/kg (325mg/kg)	?	European Patent Application. Vol. #0134762,
women	LDLo	oral	130mg/kg (130mg/kg)	?	Annals of Internal Medicine. Vol. 101, Pg. 457, 1984.
women	TDLo	intravenous	120mg/kg/3D-C (120mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	Drug Intelligence and Clinical Pharmacy. Vol. 16, Pg. 877, 1982.
women	TDLo	oral	5mg/kg (5mg/kg)	BEHAVIORAL: COMA CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) GASTROINTESTINAL: NAUSEA OR VOMITING	British Medical Journal. Vol. 288, Pg. 1497, 1984.
women	TDLo	oral	108mg/kg (108mg/kg)	ENDOCRINE: HYPERGLYCEMIA	American Journal of Emergency Medicine. Vol. 3, Pg. 408, 1985.
women	TDLo	oral	281mg/kg/4W (281mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	British Medical Journal. Vol. 281, Pg. 1322, 1980.
women	TDLo	oral	388mg/kg (388mg/kg)	BEHAVIORAL: COMA CARDIAC: CHANGE IN RATE	Annals of Emergency Medicine. Vol. 20, Pg. 1135, 1991.

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1H-Purine-2,6-dione,3,9-dihydro-1,3-dimethyl- cas no:58-55-9

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