58-73-1|Ethanamine,2-(diphenylmethoxy)-N,N-dimethyl-Products Supply

Ethanamine,2-(diphenylmethoxy)-N,N-dimethyl- cas no:58-73-1

Synonyms: Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-;Ethylamine,2-(diphenylmethoxy)-N,N-dimethyl- (7CI,8CI);2-(Diphenylmethoxy)-N,N-dimethylethylamine;Benzhydramine;Dimedrol base;FAR 90X2;N-[2-(Diphenylmethoxy)ethyl]-N,N-dimethylamine;O-Benzhydryldimethylaminoethanol;Probedryl;a-(2-Dimethylaminoethoxy)diphenylmethane;b-Dimethylaminoethylbenzhydrylether;

Identification

NameEthanamine,2-(diphenylmethoxy)-N,N-dimethyl-
CAS58-73-1
SynonymsEthanamine, 2-(diphenylmethoxy)-N,N-dimethyl-;Ethylamine,2-(diphenylmethoxy)-N,N-dimethyl- (7CI,8CI);2-(Diphenylmethoxy)-N,N-dimethylethylamine;Benzhydramine;Dimedrol base;FAR 90X2;N-[2-(Diphenylmethoxy)ethyl]-N,N-dimethylamine;O-Benzhydryldimethylaminoethanol;Probedryl;a-(2-Dimethylaminoethoxy)diphenylmethane;b-Dimethylaminoethylbenzhydrylether;
EINECS(EC#)200-396-7
Molecular FormulaC₁₇H₂₁NO
Molecular Weight255.36

Chemical Properties

Appearanceclear light yellow liquid

Safety Data

Safety

Deadly human poison by an unspecified route. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. Human systemic effects by ingestion: somnolence, alteration of operant conditioning, changes in psychophysiological tests. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intraperitoneal	75mg/kg (75mg/kg)	?	Therapie. Vol. 28, Pg. 767, 1973.
guinea pig	LD50	subcutaneous	56mg/kg (56mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 189, 1954.
human	TDLo	oral	714ug/kg (0.714mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS	Drug Development Research. Vol. 27, Pg. 33, 1992.
man	LDLo	unreported	7353ug/kg (7.353mg/kg)	?	"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LD50	intraperitoneal	56mg/kg (56mg/kg)	?	Yakkyoku. Pharmacy. Vol. 34, Pg. 27, 1983.
mouse	LD50	intravenous	29mg/kg (29mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Russian Pharmacology and Toxicology Vol. 40, Pg. 42, 1977.
mouse	LD50	oral	160mg/kg (160mg/kg)	?	Chimica Therapeutica. Vol. 7, Pg. 224, 1972.
mouse	LD50	subcutaneous	50mg/kg (50mg/kg)	?	Bollettino Chimico Farmaceutico. Vol. 111, Pg. 293, 1972.
rat	LD50	intraperitoneal	280mg/kg (280mg/kg)	?	Indian Journal of Medical Research. Vol. 59, Pg. 614, 1971.
rat	LD50	intravenous	42mg/kg (42mg/kg)	?	Drugs in Japan Vol. -, Pg. 476, 1990.
rat	LD50	oral	390mg/kg (390mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Russian Pharmacology and Toxicology Vol. 40, Pg. 42, 1977.
rat	LD50	subcutaneous	474mg/kg (474mg/kg)	?	Drugs in Japan Vol. -, Pg. 476, 1990.
women	TDLo	multiple routes	793ug/kg/1H-I (0.793mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Pharmacotherapy Vol. 14, Pg. 492, 1994.
women	TDLo	oral	30mg/kg (30mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Deutsche Medizinische Wochenschrift. Vol. 120, Pg. 1695, 1995.
women	TDLo	oral	82mg/kg (82mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: COMA	Toxicology Letters. Vol. 109(Suppl,
women	TDLo	oral	178mg/kg (178mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Annals of Emergency Medicine. Vol. 33, Pg. 104, 1999.

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Ethanamine,2-(diphenylmethoxy)-N,N-dimethyl- cas no:58-73-1

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