D-Biotin cas no:58-85-5
Synonyms: 1H-Thieno[3,4-d]imidazole-4-pentanoicacid, hexahydro-2-oxo-, (3aS,4S,6aR)-;1H-Thieno[3,4-d]imidazole-4-pentanoicacid, hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]-;Biotin (8CI);(+)-Biotin;(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid;Biodermatin;Bios II;Coenzyme R;D(+)-Biotin;Factor S;Factor S (vitamin);Lutavit H2;Meribin;NSC 63865;Rovimix H 2;Vitamin B7;Vitamin H;cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid;Biotin;
NameD-Biotin
CAS58-85-5
Synonyms1H-Thieno[3,4-d]imidazole-4-pentanoicacid, hexahydro-2-oxo-, (3aS,4S,6aR)-;1H-Thieno[3,4-d]imidazole-4-pentanoicacid, hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]-;Biotin (8CI);(+)-Biotin;(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid;Biodermatin;Bios II;Coenzyme R;D(+)-Biotin;Factor S;Factor S (vitamin);Lutavit H2;Meribin;NSC 63865;Rovimix H 2;Vitamin B7;Vitamin H;cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid;Biotin;
EINECS(EC#)200-399-3
Molecular FormulaC10H16N2O3S
Molecular Weight244.31
AppearanceWhite powder
alpha89 o (C=1, 0.1N NAOH)
refractive index90.5 ° (C=2, 0.1mol/L NaOH)
storage temp2-8°C
Hazard Xn
Risk 20/21/22-36/37/38
Safety
An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx.
Hazard Codes:?Xn
Risk Statements: 20/21/22-36/37/38?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26?
S24/25:Avoid contact with skin and eyes.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
HS Code 29362930
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XJ9088200
- CHEMICAL NAME :
- 1H-Thieno(3,4-d)imidazole-4-pentanoic acid,
hexahydro-2-oxo-, (3aS-(3a-alpha,4-beta, 6a-alpha))-
- CAS REGISTRY NUMBER :
- 58-85-5
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C10-H16-N2-O3-S
- MOLECULAR WEIGHT :
- 244.34
- WISWESSER LINE NOTATION :
- T55 BMVM GSTJ H4VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 14-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- REFERENCE :
- JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center
for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19-
1973- Volume(issue)/page/year: 22,181,1976
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- REFERENCE :
- CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O.,
Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year:
42,613,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 1-2 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
- REFERENCE :
- JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center
for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19-
1973- Volume(issue)/page/year: 21,89,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 17 mg/kg
- SEX/DURATION :
- female 1-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects
- REFERENCE :
- EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 52,149,1996
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80381
No. of Facilities: 129 (estimated)
No. of Industries: 2
No. of Occupations: 8
No. of Employees: 8306 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80381
No. of Facilities: 1674 (estimated)
No. of Industries: 9
No. of Occupations: 41
No. of Employees: 46583 (estimated)
No. of Female Employees: 22672 (estimated)
