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Hydrochlorothiazide cas no:58-93-5

Synonyms: 3,4-Dihydrochlorothiazide;Prestwick_263;6-Chloro-7-sulfamoyl-3, 4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide;Maschitt;Newtolide;3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothiadiazine-1,1-dioxide;component of Esimil;Dihydrochlorothiazid;Idrotiazide;Hydril;Drenol;Hydrochlorothiazid;Thiuretic;Hidrotiazida;Hydro-Diuril;Hydro-Aquil;Megadiuril;HCTZ;Aquarius;Component of Aldoril;2H-1,2,4-Benzothiadiazine-7-sulfonamide,6- chloro-3,4-dihydro-,1,1-dioxide;6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;Jen-Diril;Hidrochlortiazid;Esidrex;Disalunil;

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Identification
NameHydrochlorothiazide
CAS58-93-5
Synonyms3,4-Dihydrochlorothiazide;Prestwick_263;6-Chloro-7-sulfamoyl-3, 4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide;Maschitt;Newtolide;3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothiadiazine-1,1-dioxide;component of Esimil;Dihydrochlorothiazid;Idrotiazide;Hydril;Drenol;Hydrochlorothiazid;Thiuretic;Hidrotiazida;Hydro-Diuril;Hydro-Aquil;Megadiuril;HCTZ;Aquarius;Component of Aldoril;2H-1,2,4-Benzothiadiazine-7-sulfonamide,6- chloro-3,4-dihydro-,1,1-dioxide;6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;Jen-Diril;Hidrochlortiazid;Esidrex;Disalunil;
EINECS(EC#)200-403-3
Molecular FormulaC7H8ClN3O4S2
Molecular Weight297.73912
Chemical Properties
Appearancewhite crystalline powder
refractive index1.632
storage temp2-8°C
Safety Data

Hazard Xi,T,F
Risk R22
Safety

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: Sodium level changes, CHLORINE level changes, acute pulmonary edema, nausea or vomiting. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. A diuretic. When heated to decomposition it emits very toxic fumes of SOx, Cl?, and NOx.
Hazard Codes: Xi??,? T??,F ?
Risk Statements: 22-42/43-36/38-23/25-36/37/38?
R22:Harmful if swallowed.?
R42/43:May cause sensitization by inhalation and skin contact.?
R36/38:Irritating to eyes and skin.?
R23/25:Toxic by inhalation and if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24-36/37-45-33-16-7-36/37/39-27-26?
S22:Do not breathe dust.?
S24:Avoid contact with skin.?
S36/37:Wear suitable protective clothing and gloves.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S33:Take precautionary measures against static discharges.?
S16:Keep away from sources of ignition.?
S7:Keep container tightly closed.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S27:Take off immediately all contaminated clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 1230 3/PG 2
RTECS: DK9100000
Hazard Note: Irritant


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 250mg/kg (250mg/kg) ? "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
man TDLo oral 12857ug/kg/9D (12.857mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING		 American Journal of Medicine. Vol. 70, Pg. 1163, 1981.
man TDLo oral 75mg/kg/30W-I (75mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: OTHER CHANGES		 Rinsho Shinkeigaku. Clinical Neurology. Vol. 17, Pg. 162, 1977.
mouse LD50 intraperitoneal 578mg/kg (578mg/kg) ? "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 77, 1965.
mouse LD50 intravenous 590mg/kg (590mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961.
mouse LD50 oral 1175mg/kg (1175mg/kg) ? Farmatsevtichnii Zhurnal Vol. (1), Pg. 44, 1983.
mouse LD50 subcutaneous 1470mg/kg (1470mg/kg) ? "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
mouse LD50 unreported 1100mg/kg (1100mg/kg) ? Farmatsevtichnii Zhurnal Vol. (5), Pg. 26, 1983.
rabbit LD50 intravenous 461mg/kg (461mg/kg) ? "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
rat LD50 intraperitoneal 234mg/kg (234mg/kg) ? "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
rat LD50 intravenous 990mg/kg (990mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 140, Pg. 249, 1963.
rat LD50 oral 2750mg/kg (2750mg/kg) ? Toxicology and Applied Pharmacology. Vol. 1, Pg. 333, 1959.
rat LD50 subcutaneous 1270mg/kg (1270mg/kg) ? "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
women LDLo oral 2500ug/kg/5D- (2.5mg/kg) BEHAVIORAL: COMA American Journal of Medicine. Vol. 70, Pg. 1163, 1981.
women TDLo oral 250ug/kg (0.25mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

VASCULAR: SHOCK		 Annals of Pharmacotherpy. Vol. 29, Pg. 701, 1995.
women TDLo oral 500ug/kg (0.5mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Lancet. Vol. 348, Pg. 1035, 1996.
women TDLo oral 500ug/kg (0.5mg/kg) ? Israel Journal of Medical Sciences. Vol. 28, Pg. 880, 1992.
women TDLo oral 500ug/kg (0.5mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Annals of Emergency Medicine. Vol. 16, Pg. 901, 1987.
women TDLo oral 500ug/kg (0.5mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

GASTROINTESTINAL: NAUSEA OR VOMITING		 Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 238, 1984.
women TDLo oral 2mg/kg/12H-I (2mg/kg) ? Southern Medical Journal. Vol. 76, Pg. 1363, 1983.
women TDLo oral 2mg/kg/12H-I (2mg/kg) ? Southern Medical Journal. Vol. 76, Pg. 1363, 1983.
women TDLo oral 34884ug/kg/30 (34.884mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"		 Tokyo Joshi Ika Daigaku Zasshi. Journal of Tokyo Women's Medical College. Vol. 53, Pg. 1226, 1983

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