58-93-5|HydrochlorothiazideProducts Supply - Chemical intermediates Network

Hydrochlorothiazide cas no:58-93-5

Synonyms: 3,4-Dihydrochlorothiazide;Prestwick_263;6-Chloro-7-sulfamoyl-3, 4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide;Maschitt;Newtolide;3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothiadiazine-1,1-dioxide;component of Esimil;Dihydrochlorothiazid;Idrotiazide;Hydril;Drenol;Hydrochlorothiazid;Thiuretic;Hidrotiazida;Hydro-Diuril;Hydro-Aquil;Megadiuril;HCTZ;Aquarius;Component of Aldoril;2H-1,2,4-Benzothiadiazine-7-sulfonamide,6- chloro-3,4-dihydro-,1,1-dioxide;6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;Jen-Diril;Hidrochlortiazid;Esidrex;Disalunil;

Identification

NameHydrochlorothiazide
CAS58-93-5
Synonyms3,4-Dihydrochlorothiazide;Prestwick_263;6-Chloro-7-sulfamoyl-3, 4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide;Maschitt;Newtolide;3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothiadiazine-1,1-dioxide;component of Esimil;Dihydrochlorothiazid;Idrotiazide;Hydril;Drenol;Hydrochlorothiazid;Thiuretic;Hidrotiazida;Hydro-Diuril;Hydro-Aquil;Megadiuril;HCTZ;Aquarius;Component of Aldoril;2H-1,2,4-Benzothiadiazine-7-sulfonamide,6- chloro-3,4-dihydro-,1,1-dioxide;6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;Jen-Diril;Hidrochlortiazid;Esidrex;Disalunil;
EINECS(EC#)200-403-3
Molecular FormulaC7H8ClN3O4S2
Molecular Weight297.73912

Chemical Properties

Appearancewhite crystalline powder
refractive index1.632
storage temp2-8°C

Safety Data

Hazard Xi,T,F
Risk R22
Safety

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: Sodium level changes, CHLORINE level changes, acute pulmonary edema, nausea or vomiting. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. A diuretic. When heated to decomposition it emits very toxic fumes of SO_x, Cl^?, and NO_x.
Hazard Codes: Xi??,? T??,F ?
Risk Statements: 22-42/43-36/38-23/25-36/37/38?
R22:Harmful if swallowed.?
R42/43:May cause sensitization by inhalation and skin contact.?
R36/38:Irritating to eyes and skin.?
R23/25:Toxic by inhalation and if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24-36/37-45-33-16-7-36/37/39-27-26?
S22:Do not breathe dust.?
S24:Avoid contact with skin.?
S36/37:Wear suitable protective clothing and gloves.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S33:Take precautionary measures against static discharges.?
S16:Keep away from sources of ignition.?
S7:Keep container tightly closed.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S27:Take off immediately all contaminated clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 1230 3/PG 2
RTECS: DK9100000
Hazard Note: Irritant

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	250mg/kg (250mg/kg)	?	"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
man	TDLo	oral	12857ug/kg/9D (12.857mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING	American Journal of Medicine. Vol. 70, Pg. 1163, 1981.
man	TDLo	oral	75mg/kg/30W-I (75mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: OTHER CHANGES	Rinsho Shinkeigaku. Clinical Neurology. Vol. 17, Pg. 162, 1977.
mouse	LD50	intraperitoneal	578mg/kg (578mg/kg)	?	"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 77, 1965.
mouse	LD50	intravenous	590mg/kg (590mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961.
mouse	LD50	oral	1175mg/kg (1175mg/kg)	?	Farmatsevtichnii Zhurnal Vol. (1), Pg. 44, 1983.
mouse	LD50	subcutaneous	1470mg/kg (1470mg/kg)	?	"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
mouse	LD50	unreported	1100mg/kg (1100mg/kg)	?	Farmatsevtichnii Zhurnal Vol. (5), Pg. 26, 1983.
rabbit	LD50	intravenous	461mg/kg (461mg/kg)	?	"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
rat	LD50	intraperitoneal	234mg/kg (234mg/kg)	?	"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
rat	LD50	intravenous	990mg/kg (990mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 140, Pg. 249, 1963.
rat	LD50	oral	2750mg/kg (2750mg/kg)	?	Toxicology and Applied Pharmacology. Vol. 1, Pg. 333, 1959.
rat	LD50	subcutaneous	1270mg/kg (1270mg/kg)	?	"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
women	LDLo	oral	2500ug/kg/5D- (2.5mg/kg)	BEHAVIORAL: COMA	American Journal of Medicine. Vol. 70, Pg. 1163, 1981.
women	TDLo	oral	250ug/kg (0.25mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA VASCULAR: SHOCK	Annals of Pharmacotherpy. Vol. 29, Pg. 701, 1995.
women	TDLo	oral	500ug/kg (0.5mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Lancet. Vol. 348, Pg. 1035, 1996.
women	TDLo	oral	500ug/kg (0.5mg/kg)	?	Israel Journal of Medical Sciences. Vol. 28, Pg. 880, 1992.
women	TDLo	oral	500ug/kg (0.5mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Annals of Emergency Medicine. Vol. 16, Pg. 901, 1987.
women	TDLo	oral	500ug/kg (0.5mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: NAUSEA OR VOMITING	Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 238, 1984.
women	TDLo	oral	2mg/kg/12H-I (2mg/kg)	?	Southern Medical Journal. Vol. 76, Pg. 1363, 1983.
women	TDLo	oral	2mg/kg/12H-I (2mg/kg)	?	Southern Medical Journal. Vol. 76, Pg. 1363, 1983.
women	TDLo	oral	34884ug/kg/30 (34.884mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	Tokyo Joshi Ika Daigaku Zasshi. Journal of Tokyo Women's Medical College. Vol. 53, Pg. 1226, 1983

supplier list

Hangzhou Starshine Pharmaceutical Co., LTD: Tel:86-571-8696517; Address: Fengqi East Road, Hangzhou, China.

SINOCHEM NINGBO LTD.: Tel:86-574-87260209 87348868; Address: 21 Jiangxia St.,Ningbo 315000 .Zhejiang. China

RenSin Chemicals Limited: Tel:+86-25-87702966; Address: 3-810RM, Jiaye international town, 158 Lushan Road,Jianye District,Nanjing 210019, China

Beijing FortuneStar S&T Development Co., Ltd.: Tel:; Address: Zhuyuan 2-2-201, Mingliuhuayuan, Beiqijia, Changping Dist., Beijing, China

Suzhou Lixin Pharmaceutical Co.,Ltd.: Tel:; Address: No.21, Tangxi Road, Suzhou New District, 215151, China

Transo-Pharm: Tel:+49 4107 8779 333; Address: B榛畉bek 5 22962 Siek Germany

Cambridge Isotope: Tel:+1-978-749-8000; Address: Cambridge Isotope Laboratories 50 Frontage Road Andover, MA 01810-5413

Taixing Chemical Co., Ltd.(TCC): Tel:+86-25-86661100; Address: 27A/B, G.E.GARDEN, 1 HANZHONG XI RD,NANJING, JS 210029, P.R.CHINA

Ancheng Pharma Limited: Tel:+86-755-82713308; Address: Flat 1812, 18/F., Min Hua Building, 7 Jing Tian Bei Steet, Futian District,Shenzhen,China

Yixing Jiangshan Bio-tech Co., Ltd. (formerly Yix...: Tel:; Address: Rm.205,7# Building, XingHua XinCun,East JieFang Road, Yixing, Jiangsu, China

Shanghai Longschem Co.,Ltd: Tel:; Address: Shanghai Jincheng Road 338 6# 1002 Room

Kingland Chemicals Company Limited: Tel:+86-571-87211518,87229835; Address: Room No. 1806-1808, Jinfeng Mansion, No.281 Zhong He Zhong Road, Hangzhou, China.

Qingdao Chinaoil Co., Ltd: Tel:; Address: 22/F,Golden Light Tower,No.56, Xianggang Zhong Road, Qingdao 266071, China

SHANGHAI TOSCO CHEMICAL: Tel:0086-21-38875216; Address: #1704,NO.555, PUDONG AVE.SHANGHAI, CHINA

Hangzhou Pharma & Chem Co.,Ltd.: Tel:+86-571-87040515; Address: Rm.1201,QinglianBldg.No,139QingchunRd,HangzhouCity,Zhejiang,China

Hydrochlorothiazide cas no:58-93-5

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