Carboprost tromethamine cas no:58551-69-2
Synonyms: Carboprost tromethamine salt;Hemabate (TN);15(S)15-Methyl pgf2-alpha tromethamine salt;Hemabate;(15S)-15-Methylprostaglandin F(sub 2alpha) tromethamine;Prostinfenem;Carboprost tromethamine (USP);U 32921E;Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, (5Z,9alpha,11alpha,13E,15S)-, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);Prosta-5,13-dien-1-oic acid,9,11,15-trihydroxy-15-methyl-,(5Z,9R,- 11R,13E,15S)-,compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);15(S)15-Methyl prostaglandin F2-alpha tromethamine;2-amino-2-(hydroxymethyl)propane-1,3-diol; 7-[(1R,2S,3R,5S)-3,5-dihydroxy-2-[(3S)-3-hydroxy-3-methyl-oct-1-enyl]cyclopentyl]hept-5-enoic acid;2-amino-2-(hydroxymethyl)propane-1,3-diol; (E)-7-[(1S,3S,5R)-3,5-dihydroxy-2-[(Z,3S)-3-hydroxy-3-methyl-oct-1-enyl]cyclopentyl]hept-5-enoic acid;Prostin / 15M;Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, (5Z,9-alpha,11-alpha,13E,15S)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);Carboprost tromethamine [USAN];(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((E)-(3S)-3-hydroxy-3-methyl-1-octenyl)cyclopentyl)-5-heptenoic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);
NameCarboprost tromethamine
CAS58551-69-2
SynonymsCarboprost tromethamine salt;Hemabate (TN);15(S)15-Methyl pgf2-alpha tromethamine salt;Hemabate;(15S)-15-Methylprostaglandin F(sub 2alpha) tromethamine;Prostinfenem;Carboprost tromethamine (USP);U 32921E;Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, (5Z,9alpha,11alpha,13E,15S)-, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);Prosta-5,13-dien-1-oic acid,9,11,15-trihydroxy-15-methyl-,(5Z,9R,- 11R,13E,15S)-,compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);15(S)15-Methyl prostaglandin F2-alpha tromethamine;2-amino-2-(hydroxymethyl)propane-1,3-diol; 7-[(1R,2S,3R,5S)-3,5-dihydroxy-2-[(3S)-3-hydroxy-3-methyl-oct-1-enyl]cyclopentyl]hept-5-enoic acid;2-amino-2-(hydroxymethyl)propane-1,3-diol; (E)-7-[(1S,3S,5R)-3,5-dihydroxy-2-[(Z,3S)-3-hydroxy-3-methyl-oct-1-enyl]cyclopentyl]hept-5-enoic acid;Prostin / 15M;Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, (5Z,9-alpha,11-alpha,13E,15S)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);Carboprost tromethamine [USAN];(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((E)-(3S)-3-hydroxy-3-methyl-1-octenyl)cyclopentyl)-5-heptenoic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);
Molecular FormulaC21H36O5.C4H11NO3
Molecular Weight489.73
Safety
Poison by intravenous route. In humans, very small amounts cause abortion by intramuscular route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| infant |
TDLo |
intramuscular |
73529ng/kg (0.073529mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 865, 1999. |
| mouse |
LD50 |
intravenous |
131mg/kg (131mg/kg) |
? |
Advances in Prostaglandin and Thromboxane Research. Vol. 4, Pg. 157, 1978. |
| rat |
LD50 |
intravenous |
25100ug/kg (25.1mg/kg) |
? |
Advances in Prostaglandin and Thromboxane Research. Vol. 4, Pg. 157, 1978. |
