58581-89-8|AzelastineProducts Supply - Chemical intermediates Network

Azelastine cas no:58581-89-8

Synonyms: 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one;

Identification

NameAzelastine
CAS58581-89-8
Synonyms4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one;
Molecular FormulaC₂₂H₂₄ClN₃O
Molecular Weight381.9

Chemical Properties

Appearancewhite crystal powder

Safety Data

Safety

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and Cl^?.

Toxicity

dog	LD50	intravenous	13700ug/kg (13.7mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: NAUSEA OR VOMITING	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
dog	LD50	oral	51300ug/kg (51.3mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: NAUSEA OR VOMITING	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
mouse	LD50	intramuscular	59700ug/kg (59.7mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse	LD50	intraperitoneal	42800ug/kg (42.8mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
mouse	LD50	intravenous	25400ug/kg (25.4mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse	LD50	oral	124mg/kg (124mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
mouse	LD50	subcutaneous	54200ug/kg (54.2mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat	LD50	intramuscular	115mg/kg (115mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat	LD50	intraperitoneal	43200ug/kg (43.2mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat	LD50	intravenous	26900ug/kg (26.9mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat	LD50	oral	310mg/kg (310mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat	LD50	subcutaneous	59600ug/kg (59.6mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981. ?

supplier list

Andexin industrial Co.,Limited: Tel:86-411-39074598; Address: No.98,Shengli road,,Jinzhou district,

BASFGLOBAL CHEMICALS: Tel:49-621-78965412; Address: Carl-Bosch-Stra?e 38 67056 Ludwigshafen

Jinan Haohua Industry Co., Ltd.: Tel:0086-531-58773055; Address: No.59 Gongye South RD

AFINE CHEMICALS LIMITED: Tel:86-571-85232161; Address: 6th Floor, Block C, 7th Building, Xigang Xinjie, Xihu Industrial Park, Sandun Town, Hangzhou, China

AOPHARM: Tel:86-311-66600578; Address: C-2103 Wonder Business Square, 15 Yuhua West Rd.

Landz International Company Ltd.: Tel:86-21-58890221; Address: Suite 305B, Building 2, 77 Eshan Road, Pudong New Area, Shanghai, China (Mainland)

MOL Pharmaceutical Laboratory Ltd: Tel:86-23-5887157; Address: No.120, Shipingqiao Str., Jiulong Science Park, Jiulongpo Dist, Chongqing 400050, P.R.C

Wujiang Yingchuang Chemical Co., Ltd.: Tel:+86-(25)-8645 8768; Address: 215 Ying Tian Da Street, JianYe, Nanjing, Jiangsu 210017,

Zhejiang Sunrise Fine Chemicals Co.,Ltd: Tel:86-574-87970875; Address: 22nd Fl.East Sea Sunshine Building No.455 Zhongshan East Rd.Ningbo 315040 China

ZHOU FANG PHARM CHEMICAL: Tel:861-348-227-9455; Address: 1230 Zhousan Road,

XinChem Corporation: Tel:+86-(21)-34123252; Address: 102/30, 3455 Chunshen Road, Shanghai 201100,

YiPeng Chemical: Tel:571 85376369; Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China

Shin Nippon Yakugyo Co.,Ltd.: Tel:81-3-3667-5941; Address: 11-7, Nihonbashi-Tomizawacho Chuo-Ku, Tokyo Japan

Suzhou T-Rainbow Pharma Co., Ltd.: Tel:86-0557-3931456; Address: NO.8 Jinhai Road , New High-Tech Industrial Development Zone Suzhou City,Anhui Province

Shanghai Chemchallenger Biotech Co., Ltd.: Tel:0086-21-68110815; Address: Room 2056, Building 1, No. 1065, Jiaxin Road Shanghai China (Mainland) 201800

Azelastine cas no:58581-89-8

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