58581-89-8|AzelastineProducts Supply - Chemical intermediates Network

Azelastine cas no:58581-89-8

Synonyms: 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one;

Identification

NameAzelastine
CAS58581-89-8
Synonyms4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one;
Molecular FormulaC₂₂H₂₄ClN₃O
Molecular Weight381.9

Chemical Properties

Appearancewhite crystal powder

Safety Data

Safety

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and Cl^?.

Toxicity

dog	LD50	intravenous	13700ug/kg (13.7mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: NAUSEA OR VOMITING	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
dog	LD50	oral	51300ug/kg (51.3mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: NAUSEA OR VOMITING	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
mouse	LD50	intramuscular	59700ug/kg (59.7mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse	LD50	intraperitoneal	42800ug/kg (42.8mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
mouse	LD50	intravenous	25400ug/kg (25.4mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse	LD50	oral	124mg/kg (124mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
mouse	LD50	subcutaneous	54200ug/kg (54.2mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat	LD50	intramuscular	115mg/kg (115mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat	LD50	intraperitoneal	43200ug/kg (43.2mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat	LD50	intravenous	26900ug/kg (26.9mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat	LD50	oral	310mg/kg (310mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat	LD50	subcutaneous	59600ug/kg (59.6mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981. ?

supplier list

Tianjin Harmony Technology Development Co., Ltd.: Tel:; Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China

Luna Chemicals Co.,Ltd.: Tel:; Address: 1502-1503,No.310 North Zhong Shan Rd., Hangzhou,China

Shangyu Zhongchang Chemical Co.,LTD.: Tel:; Address: Shangyu chemical zone,zhejiang,China

Inter-Chemical Ltd.: Tel:+86-(755)-82187211, 82192202; Address: B-1108/1109, Tian An International Bldg., RenMin Nan Road, ShenZhen 518005,

Sunwell Chemicals Co.,Ltd.: Tel:+86-(571)-87243911, 87046883; Address: Suite 1108,Golden Plaza,NO.118,Qing Chun Road, Hangzhou, 310003 Zhejiang,

Taizhou Creating Chemical Co. ,Ltd.: Tel:+86-(576)-88827176,88820069; Address: B Suite 12F,JiangbinBuilding,Jiaojiang, Taizhou, Zhejiang,

Sanmen Eastsky Pharmaceutical Co., Ltd: Tel:+86-(576)-83510058; Address: Room 8402, Saigete Garden, Dahutang Development Zone, Sanmen, Zhejiang 317100,

Jiangxi LK Pharmaceutical Co., Ltd.: Tel:+86-(796)-8260196; Address: No.119 Yanjiang Rd, Jizhou District, Ji'an, Jiangxi 343000,

Kang-Sun Pharmaceutical Limited: Tel:+86-(517)-88842817; Address: Jialv Xiyuan 15-2-602,Xihu District, HangZhou, Zhejiang,

Taizhou Intouch Chemical Co. Ltd.: Tel:+86-(576)-88698596; Address: Economic Development Zone, Taizhou, Zhejiang 318000,

Changzhou Weijia Chemical Co.,Ltd.: Tel:+86-(519)-86805358; Address: RM811, No.517 Jinling Road, Changzhou, Jiangsu 213003,

Varda Biotech Pvt. Ltd.: Tel:+91-(22)-6693 5686; Address: #110 & 111 Kartik Complex, New Link Road, Andheri (W), Mumbai, Maharashtra 400 053,

Tecoland Corporation: Tel:+1-(732)-603-9577; Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428,

Trust & We Co., Ltd.: Tel:86-21-61551611; Address: 601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong, Shanghai, China.

AOKChem Co., Ltd.: Tel:+86-(21)-50791030 / 68712331; Address: Room 203, Block D, No.333 Cailun Road, Zhangjiang High-tech Park, Shanghai 201203,

Azelastine cas no:58581-89-8

Directory

supplier list