58581-89-8|AzelastineProducts Supply - Chemical intermediates Network

Azelastine cas no:58581-89-8

Synonyms: 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one;

Identification

NameAzelastine
CAS58581-89-8
Synonyms4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one;
Molecular FormulaC₂₂H₂₄ClN₃O
Molecular Weight381.9

Chemical Properties

Appearancewhite crystal powder

Safety Data

Safety

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and Cl^?.

Toxicity

dog	LD50	intravenous	13700ug/kg (13.7mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: NAUSEA OR VOMITING	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
dog	LD50	oral	51300ug/kg (51.3mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: NAUSEA OR VOMITING	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
mouse	LD50	intramuscular	59700ug/kg (59.7mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse	LD50	intraperitoneal	42800ug/kg (42.8mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
mouse	LD50	intravenous	25400ug/kg (25.4mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse	LD50	oral	124mg/kg (124mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
mouse	LD50	subcutaneous	54200ug/kg (54.2mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat	LD50	intramuscular	115mg/kg (115mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat	LD50	intraperitoneal	43200ug/kg (43.2mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat	LD50	intravenous	26900ug/kg (26.9mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat	LD50	oral	310mg/kg (310mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat	LD50	subcutaneous	59600ug/kg (59.6mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981. ?

supplier list

Zhuhai Sanxin Fine Chemical Co., Ltd.: Tel:+86-(756)-763-0000; Address: No.6, Jichang North Road, Jinwan District, Zhuhai, Guangdong 519041,

Shanghai Renyoung Pharmaceutical Co., Ltd.: Tel:+86-(21)-35010877; Address: 16F,No.1690 Kongjiang Road, Shanghai 200092,

Manus Aktteva: Tel:+91-(79)-65123395; Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006,

KINFON PHARMACEUTICAL AND CHEMICAL CO.LTD: Tel:86-23-8650081; Address: 32F,Duhe Plaza, Lijiatuo Street, Banan Dist,Chongq

Shanghai Chemchallenger Biotech Co., Ltd.: Tel:0086-21-68110815; Address: Room 2056, Building 1, No. 1065, Jiaxin Road Shanghai China (Mainland) 201800

BASFGLOBAL CHEMICALS: Tel:49-621-78965412; Address: Carl-Bosch-Stra?e 38 67056 Ludwigshafen

Hangzhou Dayangchem Co., Ltd.: Tel:86-571-88938639; Address: 9/F Unit 2 ChangdiTorch Building, 259 #WenSan Road

Hangzhou J&H Chemical Co., Ltd: Tel:86-571-87396430; Address: No.200 Zhenhua Rd.Xihu Industrial Park, Hangzhou 310030, China

Finetech Industry limited.: Tel:86-27-87465837; Address: chukang Road, Wuhan, Hubei 430073,

run-biotech Co., Ltd.: Tel:86-21-61900721; Address: Room 3-201, No.787, Kangqiao Road, Pudong New District, Shanghai, China

Boc Sciences: Tel:1-631-5046093; Address: 45-16 Ramsey Road Shirley, NY 11967, USA

Andexin industrial Co.,Limited: Tel:86-411-39074598; Address: No.98,Shengli road,,Jinzhou district,

Jinan Haohua Industry Co., Ltd.: Tel:0086-531-58773055; Address: No.59 Gongye South RD

AFINE CHEMICALS LIMITED: Tel:86-571-85232161; Address: 6th Floor, Block C, 7th Building, Xigang Xinjie, Xihu Industrial Park, Sandun Town, Hangzhou, China

AOPHARM: Tel:86-311-66600578; Address: C-2103 Wonder Business Square, 15 Yuhua West Rd.

Azelastine cas no:58581-89-8

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