587-63-3|2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-(2-phenylethyl)-, (6S)-Products Supply

2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-(2-phenylethyl)-, (6S)- cas no:587-63-3

Synonyms: 2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-(2-phenylethyl)-, (S)-; 2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-phenethyl- (8CI); (+)-7,8-Dihydrokavain;(+)-Dihydrokavain; (+)-Dihydrokawain; (S)-(+)-Dihydrokawain; 7,8-Dihydrokavain;7,8-Dihydrokawain; Dihydrokavain; Dihydrokawain; Kawain, dihydro-; Marindinin;NSC 112163

Identification

Name2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-(2-phenylethyl)-, (6S)-
CAS587-63-3
Synonyms2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-(2-phenylethyl)-, (S)-; 2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-phenethyl- (8CI); (+)-7,8-Dihydrokavain;(+)-Dihydrokavain; (+)-Dihydrokawain; (S)-(+)-Dihydrokawain; 7,8-Dihydrokavain;7,8-Dihydrokawain; Dihydrokavain; Dihydrokawain; Kawain, dihydro-; Marindinin;NSC 112163
Molecular FormulaC14H16 O3
Molecular Weight232.27504

Chemical Properties

AppearanceWhite powder
refractive index1.544

Safety Data

Safety

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	intraperitoneal	> 250mg/kg (250mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: NAUSEA OR VOMITING	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962.
dog	LD50	intraperitoneal	> 200mg/kg (200mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: NAUSEA OR VOMITING	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962.
mouse	LD50	intraperitoneal	325mg/kg (325mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962.
mouse	LD50	intravenous	53mg/kg (53mg/kg)	BEHAVIORAL: ANTICONVULSANT	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 177, Pg. 261, 1969.
mouse	LD50	oral	920mg/kg (920mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962.
rabbit	LD50	intraperitoneal	350mg/kg (350mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962.

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2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-(2-phenylethyl)-, (6S)- cas no:587-63-3

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