58786-99-5|Butorphanol tartrateProducts Supply - Chemical intermediates Network

Butorphanol tartrate cas no:58786-99-5

Synonyms: Butorphanol tartrate (JAN/USP);Morphinan-3,14-diol,17-(cyclobutylmethyl)-,(2S,3S)-2,3-dihydroxybutanedioate (1:1) (salt);Stadol;Moradol;Stadol (TN);

Identification

NameButorphanol tartrate
CAS58786-99-5
SynonymsButorphanol tartrate (JAN/USP);Morphinan-3,14-diol,17-(cyclobutylmethyl)-,(2S,3S)-2,3-dihydroxybutanedioate (1:1) (salt);Stadol;Moradol;Stadol (TN);
EINECS(EC#)261-443-5
Molecular FormulaC₂₁H₂₉NO₂^.C₄H₆O₆
Molecular Weight477.61

Chemical Properties

storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(a)

Safety Data

Hazard Xn: Harmful;
Risk R22;R63
Safety

Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. An analgesic. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes:
Harmful Xn
Risk Statements:
R22:Harmful if swallowed.
R63:Possible risk of harm to the unborn child.
Safety Statements:
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 1544
WGK Germany: 3
RTECS: QC7795000
HazardClass: 6.1(a)
PackingGroup: II

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intramuscular	17mg/kg (17mg/kg)		Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 16, Pg. 474, 1978.
dog	LD50	intravenous	10mg/kg (10mg/kg)		Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 16, Pg. 474, 1978.
dog	LD50	oral	> 50mg/kg (50mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 19, 1979.
monkey	LD50	oral	> 50mg/kg (50mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 19, 1979.
mouse	LD50	intramuscular	208mg/kg (208mg/kg)	behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: dyspnea	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 145, 1982.
mouse	LD50	intraperitoneal	192mg/kg (192mg/kg)	behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: dyspnea	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 145, 1982.
mouse	LD50	intravenous	36mg/kg (36mg/kg)	behavioral: somnolence (general depressed activity) lungs, thorax, or respiration: dyspnea behavioral: convulsions or effect on seizure threshold	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 145, 1982.
mouse	LD50	oral	395mg/kg (395mg/kg)		Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 16, Pg. 474, 1978.
mouse	LD50	subcutaneous	299mg/kg (299mg/kg)	behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold behavioral: ataxia	Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 19, 1979.
rat	LD50	intramuscular	255mg/kg (255mg/kg)	behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: dyspnea	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 145, 1982.
rat	LD50	intraperitoneal	127mg/kg (127mg/kg)	behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: dyspnea	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 145, 1982.
rat	LD50	intravenous	17mg/kg (17mg/kg)		Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 16, Pg. 474, 1978.
rat	LD50	oral	315mg/kg (315mg/kg)	behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: dyspnea	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 145, 1982.
rat	LD50	subcutaneous	425mg/kg (425mg/kg)	behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: dyspnea	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 145, 1982.

supplier list

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Butorphanol tartrate cas no:58786-99-5

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