child |
TDLo |
intravenous |
100mg/kg/4H (100mg/kg) |
BLOOD: THROMBOCYTOPENIA
BLOOD: OTHER CHANGES |
Cancer Vol. 33, Pg. 1151, 1974. |
child |
TDLo |
oral |
2mg/kg/12D (2mg/kg) |
LUNGS, THORAX, OR RESPIRATION: COUGH
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
JAMA, Journal of the American Medical Association. Vol. 209, Pg. 1861, 1969. |
human |
TDLo |
intramuscular |
35mg/kg/28W (35mg/kg) |
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
LUNGS, THORAX, OR RESPIRATION: CYANOSIS |
British Medical Journal. Vol. 2, Pg. 156, 1970. |
human |
TDLo |
intramuscular |
200mg/kg/5Y (200mg/kg) |
LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)" |
Archives of Dermatology. Vol. 100, Pg. 531, 1969. |
human |
TDLo |
intravenous |
4650ug/kg/4W- (4.65mg/kg) |
LIVER: FATTY LIVER DEGERATION
LIVER: LIVER FUNCTION TESTS IMPAIRED |
Proceedings of the American Association for Cancer Research. Vol. 5, Pg. 26, 1964. |
human |
TDLo |
intravenous |
7143ug/kg (7.143mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING
BLOOD: CHANGES IN PLATELET COUNT
BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT |
Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 27, Pg. 673, 1992. |
human |
TDLo |
oral |
43mg/kg/5Y (43mg/kg) |
LIVER: LIVER FUNCTION TESTS IMPAIRED
LIVER: OTHER CHANGES |
Archives of Dermatology. Vol. 100, Pg. 523, 1969. |
man |
TDLo |
intramuscular |
214ug/kg/12D- (0.214mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Clinical and Experimental Rheumatology. Vol. 14, Pg. 450, 1996. |
man |
TDLo |
intravenous |
740mg/kg (740mg/kg) |
GASTROINTESTINAL: OTHER CHANGES |
Archives of Internal Medicine. Vol. 136, Pg. 1321, 1976. |
man |
TDLo |
oral |
643ug/kg/6W-I (0.643mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Journal of Rheumatology. Vol. 14, Pg. 74, 1987. |
man |
TDLo |
oral |
4286ug/kg/2.7 (4.286mg/kg) |
LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION
BLOOD: APLASTIC ANEMIA |
Clinical Rheumatology. Vol. 12, Pg. 535, 1993. |
mouse |
LD50 |
intraperitoneal |
50mg/kg (50mg/kg) |
? |
Anatomical Record. Vol. 178, Pg. 465, 1974. |
mouse |
LD50 |
intravenous |
65mg/kg (65mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 841, 1982. |
mouse |
LD50 |
oral |
146mg/kg (146mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 841, 1982. |
mouse |
LD50 |
subcutaneous |
250mg/kg (250mg/kg) |
? |
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, |
mouse |
LD50 |
unreported |
69mg/kg (69mg/kg) |
? |
Cancer Research. Vol. 46, Pg. 2703, 1986.
Link to PubMed |
rat |
LD50 |
intraperitoneal |
6mg/kg (6mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 841, 1982. |
rat |
LD50 |
intravenous |
14mg/kg (14mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1467, 1970.
Link to PubMed |
rat |
LD50 |
oral |
135mg/kg (135mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 841, 1982. |
rat |
LD50 |
subcutaneous |
58mg/kg (58mg/kg) |
? |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992. |
rat |
LD50 |
unreported |
133ug/kg (0.133mg/kg) |
? |
United States Patent Document. Vol. #4746662, |
women |
LDLo |
intraspinal |
36mg/kg/15D (36mg/kg) |
SPINAL CORD: OTHER DEGENERATIVE CHANGES
GASTROINTESTINAL: NAUSEA OR VOMITING |
New England Journal of Medicine. Vol. 289, Pg. 770, 1973. |
women |
TDLo |
oral |
800ug/kg/4D-I (0.8mg/kg) |
BLOOD: LEUKOPENIA
BLOOD: THROMBOCYTOPENIA
BLOOD: OXIDANT RELATED (GPD DEFICIENT) ANEMIA |
Medical Journal of Australia. Vol. 155, Pg. 493, 1991. |
women |
TDLo |
oral |
2mg/kg/17W-I (2mg/kg) |
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BLOOD: LEUKOPENIA |
Journal of Rheumatology. Vol. 14, Pg. 74, 1987. |
women |
TDLo |
parenteral |
2600ug/kg (2.6mg/kg) |
BRAIN AND COVERINGS: CHANGES IN CEREBRAL SPINAL FLUID
LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Cancer Vol. 38, Pg. 1529, 1976. |
women |
TDLo |
unreported |
11400ug/kg/44 (11.4mg/kg) |
LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" |
Clinical and Experimental Rheumatology. Vol. 15, Pg. 583, 1997. |
women |
TDLo |
unreported |
150mg/kg (150mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE |
Cancer Vol. 48, Pg. 2158, 1981. |