Pyramal maleate cas no:59-33-6
Synonyms: 1,2-Ethanediamine, N1-[(4-methoxyphenyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl-, (2Z)-2-butenedioate (1:1);ANTHISAN;histosol;N-(4-Methoxybenzyl)-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine (2Z)-2-butenedioate (1:1);N-(4-Methoxybenzyl)-N',N'-dimethyl-N-(pyridin-2-yl)ethane-1,2-diamine (2Z)-but-2-enedioate (1:1);N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine (2Z)-but-2-enedioate;N-[(4-Methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine (2Z)-2-Butenedioate (1:1);N-p-Methoxybenzyl-N',N'-dimethyl-N-a-pyridylethylenediamine Maleate;Thylogen;
NamePyramal maleate
CAS59-33-6
Synonyms1,2-Ethanediamine, N1-[(4-methoxyphenyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl-, (2Z)-2-butenedioate (1:1);ANTHISAN;histosol;N-(4-Methoxybenzyl)-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine (2Z)-2-butenedioate (1:1);N-(4-Methoxybenzyl)-N',N'-dimethyl-N-(pyridin-2-yl)ethane-1,2-diamine (2Z)-but-2-enedioate (1:1);N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine (2Z)-but-2-enedioate;N-[(4-Methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine (2Z)-2-Butenedioate (1:1);N-p-Methoxybenzyl-N',N'-dimethyl-N-a-pyridylethylenediamine Maleate;Thylogen;
EINECS(EC#)200-422-7
Molecular FormulaC17H23N3O•C4H4O4
Molecular Weight401.45618
Appearancewhite crystalline powder
storage temp2-8°C
Hazard Xn: Harmful;
Risk R22;R36/37/38
Safety
A human poison by ingestion. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. An antihistamine. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Pyrilamine maleate (CAS NO.59-33-6):
Hazard Codes: Xn.gif)
Risk Statements: 22-36/37/38
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements: 26-36/37
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| child |
LDLo |
oral |
42mg/kg (42mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
GASTROINTESTINAL: NAUSEA OR VOMITING |
Lancet. Vol. 2, Pg. 809, 1952. |
| guinea pig |
LD50 |
intravenous |
24400ug/kg (24.4mg/kg) |
|
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958. |
| guinea pig |
LD50 |
subcutaneous |
44mg/kg (44mg/kg) |
|
Annales Pharmaceutiques Francaises. Vol. 20, Pg. 463, 1962. |
| mouse |
LD50 |
intraperitoneal |
100mg/kg (100mg/kg) |
|
Planta Medica. Vol. 42, Pg. 75, 1981. |
| mouse |
LD50 |
intravenous |
23mg/kg (23mg/kg) |
|
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 47, 1965. |
| mouse |
LD50 |
oral |
220mg/kg (220mg/kg) |
|
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 47, 1965. |
| mouse |
LD50 |
subcutaneous |
141mg/kg (141mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 940, 1964. |
| rat |
LD50 |
oral |
513mg/kg (513mg/kg) |
|
Toxicology and Applied Pharmacology. Vol. 1, Pg. 42, 1959. |
| rat |
LDLo |
subcutaneous |
150mg/kg (150mg/kg) |
BEHAVIORAL: TREMOR |
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 144, Pg. 887, 1950. |
| women |
TDLo |
oral |
200mg/kg (200mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
CARDIAC: OTHER CHANGES
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION |
JAMA, Journal of the American Medical Association. Vol. 257, Pg. 660, 1987. |
