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Procaine cas no:59-46-1

Synonyms: Benzoicacid, p-amino-, 2-(diethylamino)ethyl ester (8CI);2-(Diethylamino)ethylp-aminobenzoate;2-Diethylaminoethyl 4-aminobenzoate;4-Aminobenzoic acid2-(diethylamino)ethyl ester;4-Aminobenzoic acid diethylaminoethyl ester;Diethylaminoethyl p-aminobenzoate;Duracaine;Nissocaine;PfizerpenAS;Procain;Procaine base;SP 01;Spinocaine;Vitamin H3;p-Aminobenzoic acid 2-diethylaminoethyl ester;b-(Diethylamino)ethyl p-aminobenzoate;b-Diethylaminoethyl4-aminobenzoate;

Identification
NameProcaine
CAS59-46-1
SynonymsBenzoicacid, p-amino-, 2-(diethylamino)ethyl ester (8CI);2-(Diethylamino)ethylp-aminobenzoate;2-Diethylaminoethyl 4-aminobenzoate;4-Aminobenzoic acid2-(diethylamino)ethyl ester;4-Aminobenzoic acid diethylaminoethyl ester;Diethylaminoethyl p-aminobenzoate;Duracaine;Nissocaine;PfizerpenAS;Procain;Procaine base;SP 01;Spinocaine;Vitamin H3;p-Aminobenzoic acid 2-diethylaminoethyl ester;b-(Diethylamino)ethyl p-aminobenzoate;b-Diethylaminoethyl4-aminobenzoate;
EINECS(EC#)200-426-9
Molecular FormulaC13H20N2O2
Molecular Weight236.31
Chemical Properties
refractive index1.542
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Safety

Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by parenteral route. Human systemic effects by intramuscular route: lack of muscular control, rigidity, and possibly catalepsy. See also ESTERS. When heated to decomposition it emits toxic fumes of NOx. Used as a local anesthetic.
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III


Toxicity
1.    

orl-man LDLo:147 mg/kg

    85DCAI    Poisoning; Toxicology, Symptoms, Treatments. 2 (1970),73.
2.    

ims-wmn TDLo:1600 µg/kg:CNS

    JNNPAU    Journal of Neurology, Neurosurgery and Psychiatry. 34 (1971),20.
3.    

ipr-rat LDLo:280 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 1 (1959),156.
4.    

scu-rat LD50:600 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 104 (1956),388.
5.    

ivn-rat LDLo:45 mg/kg

    PHREA7    Physiological Reviews. 12 (1932),190.
6.    

orl-mus LD50:350 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 16 (1966),1275.
7.    

ipr-mus LD50:124 mg/kg

    RPOBAR    Research Progress in Organic Biological and Medicinal Chemistry. 2 (1970),213.
8.    

scu-mus LD50:300 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 5 (1955),376.
9.    

ivn-mus LD50:45 mg/kg

    JAPMA8    Journal of the American Pharmaceutical Association, Scientific Edition. 45 (1956),382.

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Suntin MediPharma Co. Ltd.
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Yurui(Shanghai) Chemical Co.,Ltd
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Huangshi Topwell Biotech Co.,Ltd
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Hangzhou Utanpharma biology co,.Ltd
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Hubei XinRunde Chemical Co., Ltd
Tel:86-27-83214668
Address: East and West Lake District, Wuhan, China
Hubei XinRunde Chemical Co., Ltd
Tel:86-27-83214668
Address: East and West Lake District, Wuhan, China
Hubei XinRunde Chemical Co., Ltd
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Address: East and West Lake District, Wuhan, China
Wuhan H.X.K Fine Chemicals Co.,LTD
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Address: No. 139, hanyang Road, hubei city, Hubei Prov. China 434000
Nanjing Bangnuo Biotechnology Co., Ltd.
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Hubei Yuancheng Saichuang Technology Co., Ltd
Tel:86-27-68886732
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Hubei Yuancheng Saichuang Technology Co., Ltd
Tel:86-27-68886732
Address: 28# Golden Avenue, Golden Industrial Zone, Zhengdian Street, Jiangxia District, Wuhan City, Hubei, P. R. China
Nanjing Bangnuo Biotechnology Co., Ltd.
Tel:86-25-52113793
Address: Room 901 Tianqinwan Garden NO.1008 Ssangyong Avenu
Wuhan Dahua Weiye Pharmaceutical Co.,Ltd
Tel:86-27-59335372
Address: daijiashan 45,jiangan economic departmen zone,wuhan,hubei,China
Hebei yanxi chemical co., LTD
Tel:86-311-66561638
Address: Zhang zhe, guangzong county, xingtai city, hebei p
Guangzhoushi Huao Chemical Co.,Ltd.
Tel:86-185-78209868
Address: Guangzhoushi nansha

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