59-46-1|ProcaineProducts Supply - Chemical intermediates Network

Procaine cas no:59-46-1

Synonyms: Benzoicacid, p-amino-, 2-(diethylamino)ethyl ester (8CI);2-(Diethylamino)ethylp-aminobenzoate;2-Diethylaminoethyl 4-aminobenzoate;4-Aminobenzoic acid2-(diethylamino)ethyl ester;4-Aminobenzoic acid diethylaminoethyl ester;Diethylaminoethyl p-aminobenzoate;Duracaine;Nissocaine;PfizerpenAS;Procain;Procaine base;SP 01;Spinocaine;Vitamin H3;p-Aminobenzoic acid 2-diethylaminoethyl ester;b-(Diethylamino)ethyl p-aminobenzoate;b-Diethylaminoethyl4-aminobenzoate;

Identification

NameProcaine
CAS59-46-1
SynonymsBenzoicacid, p-amino-, 2-(diethylamino)ethyl ester (8CI);2-(Diethylamino)ethylp-aminobenzoate;2-Diethylaminoethyl 4-aminobenzoate;4-Aminobenzoic acid2-(diethylamino)ethyl ester;4-Aminobenzoic acid diethylaminoethyl ester;Diethylaminoethyl p-aminobenzoate;Duracaine;Nissocaine;PfizerpenAS;Procain;Procaine base;SP 01;Spinocaine;Vitamin H3;p-Aminobenzoic acid 2-diethylaminoethyl ester;b-(Diethylamino)ethyl p-aminobenzoate;b-Diethylaminoethyl4-aminobenzoate;
EINECS(EC#)200-426-9
Molecular FormulaC13H20N2O2
Molecular Weight236.31

Chemical Properties

refractive index1.542

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Safety

Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by parenteral route. Human systemic effects by intramuscular route: lack of muscular control, rigidity, and possibly catalepsy. See also ESTERS. When heated to decomposition it emits toxic fumes of NO_x. Used as a local anesthetic.
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III

Toxicity

1.	orl-man LDLo:147 mg/kg	85DCAI Poisoning; Toxicology, Symptoms, Treatments. 2 (1970),73.
2.	ims-wmn TDLo:1600 µg/kg:CNS	JNNPAU Journal of Neurology, Neurosurgery and Psychiatry. 34 (1971),20.
3.	ipr-rat LDLo:280 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 1 (1959),156.
4.	scu-rat LD50:600 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 104 (1956),388.
5.	ivn-rat LDLo:45 mg/kg	PHREA7 Physiological Reviews. 12 (1932),190.
6.	orl-mus LD50:350 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 16 (1966),1275.
7.	ipr-mus LD50:124 mg/kg	RPOBAR Research Progress in Organic Biological and Medicinal Chemistry. 2 (1970),213.
8.	scu-mus LD50:300 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 5 (1955),376.
9.	ivn-mus LD50:45 mg/kg	JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 45 (1956),382.

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Procaine cas no:59-46-1

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