59-67-6|Nicotinic acidProducts Supply - Chemical intermediates Network

Nicotinic acid cas no:59-67-6

Synonyms: Nicocidin;Efacin;Nicocap;Niacor;Niac;Nicamin;Nicotinipca;Daskil;Nicotene;Nicosan 3;Nicodon;Nicobid;Davitamon PP;pyridine-3-carboxylate;NICO;Peviton;Nicovasan;Nicotamin;Pellagrin;Niconat;Enduracin;Nicangin;Nicodelmine;Niacin (vitamin B3);Nicotinic acid(Medicine used);Nikotinsaeure;Niacin;

Identification

NameNicotinic acid
CAS59-67-6
SynonymsNicocidin;Efacin;Nicocap;Niacor;Niac;Nicamin;Nicotinipca;Daskil;Nicotene;Nicosan 3;Nicodon;Nicobid;Davitamon PP;pyridine-3-carboxylate;NICO;Peviton;Nicovasan;Nicotamin;Pellagrin;Niconat;Enduracin;Nicangin;Nicodelmine;Niacin (vitamin B3);Nicotinic acid(Medicine used);Nikotinsaeure;Niacin;
EINECS(EC#)200-441-0
Molecular FormulaC₆H₅NO₂
Molecular Weight123.11

Chemical Properties

AppearanceWhite crystalline powder
refractive index1.4936
storage temp0-6°C

Safety Data

Hazard Xi:;
Risk R36/37/38
Safety

Poison by intraperitoneal route. Moderately toxic by ingestion, intravenous, and subcutaneous routes. Human systemic effects: change in clotting factors, changes in platelet count. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes:?Xi
Risk Statements: 36/37/38?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.?
S24/25: Avoid contact with skin and eyes.
WGK Germany of Niacin (CAS NO.59-67-6): 1

HS Code 29362990

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	intravenous	3500mg/kg (3500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Proceedings of the Society for Experimental Biology and Medicine. Vol. 38, Pg. 241, 1938.
man	TDLo	intravenous	357ug/kg (0.357mg/kg)	CARDIAC: CARDIAC OUTPUT LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Annals of Internal Medicine. Vol. 29, Pg. 558, 1948.
man	TDLo	oral	2571mg/kg/90D (2571mg/kg)	BLOOD: CHANGE IN CLOTTING FACTORS BLOOD: CHANGES IN PLATELET COUNT	Archives of Internal Medicine. Vol. 152, Pg. 861, 1992.
man	TDLo	oral	9713mg/kg/58W (9713mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	Southern Medical Journal. Vol. 84, Pg. 496, 1991.
man	TDLo	oral	31200mg/kg/78 (31200mg/kg)	SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	JAMA, Journal of the American Medical Association. Vol. 279, Pg. 1702, 1998.
mouse	LD50	intraperitoneal	358mg/kg (358mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977.
mouse	LD50	intravenous	5gm/kg (5000mg/kg)	?	Therapie. Vol. 26, Pg. 831, 1971.
mouse	LD50	oral	3720mg/kg (3720mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 149, 1973.
mouse	LD50	subcutaneous	3500mg/kg (3500mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977.
mouse	LD50	unreported	4gm/kg (4000mg/kg)	?	British UK Patent Application. Vol. #2041937,
rabbit	LD50	oral	4550mg/kg (4550mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977.
rat	LD50	intraperitoneal	730mg/kg (730mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977.
rat	LD50	oral	7gm/kg (7000mg/kg)	?	Drugs in Japan Vol. 6, Pg. 544, 1982.
rat	LD50	subcutaneous	5gm/kg (5000mg/kg)	?	Drugs in Japan Vol. 6, Pg. 544, 1982.
rat	LD50	unreported	4gm/kg (4000mg/kg)	?	United States Patent Document. Vol. #4412998,
rat	LDLo	intravenous	3500mg/kg (3500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Proceedings of the Society for Experimental Biology and Medicine. Vol. 38, Pg. 241, 1938.

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Nicotinic acid cas no:59-67-6

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