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Morpholine, 4-nitroso- cas no:59-89-2

Synonyms: 4-Nitrosomorpholine;N-Nitrosomorpholine; NSC 139; Nitrosomorpholine

Identification
NameMorpholine, 4-nitroso-
CAS59-89-2
Synonyms4-Nitrosomorpholine;N-Nitrosomorpholine; NSC 139; Nitrosomorpholine
Molecular FormulaC4H8 N2 O2
Molecular Weight116.11852
Chemical Properties
Appearanceyellow crystals or gold liquid
refractive index1.573
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard Xn,T,F
Risk 22-40-39/23/24/25-23/24/25-11
Safety

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Human mutation data reported. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.
 

Hazard Codes: Xn,T,F
Risk Statements:
11:  Highly Flammable
22:  Harmful if swallowed
23:  Toxic by inhalation
24:  Toxic in contact with skin
25:  Toxic if swallowed
39:  Danger of very serious irreversible effects
40:  Limited evidence of a carcinogenic effect
Safety Statements:
16:  Keep away from sources of ignition - No smoking
17:  Keep away from combustible material
36:  Wear suitable protective clothing 
37:  Wear suitable gloves
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)


Toxicity
1.    

slt-dmg-orl 210 µmol/kg

    MUREAV    Mutation Research. 144 (1985),177.
2.    

dns-hmn:fbr 160 µg/L

    PMRSDJ    Progress in Mutation Research. 1 (1981),528.
3.    

orl-mus TDLo:3140 mg/kg/28W-C:NEO

    JNCIAM    Journal of the National Cancer Institute. 46 (1971),1029.
4.    

orl-rat TD:180 mg/kg/I:ETA,REP

    ZEKBAI    Zeitschrift fuer Krebsforschung. 66 (1964),1.
5.    

orl-rat LD50:282 mg/kg

    NATWAY    Naturwissenschaften. 48 (1961),134.
6.    

ipr-rat LD50:282 mg/kg

    BJIMAG    British Journal of Industrial Medicine. 19 (1962),276.
7.    

scu-rat LD50:170 mg/kg

    ZKKOBW    Zeitschrift fuer Krebsforschung und Klinische Onkologie. 80 (1973),17.
8.    

ivn-rat LD50:98 mg/kg

    ZEKBAI    Zeitschrift fuer Krebsforschung. 69 (1967),103.
9.    

ihl-mus LCLo:1000 mg/m3/10M

    NDRC**    National Defense Research Committee, Office of Scientific Research and Development, Progress Report NDCrc-132,Sept ,1942.
10.    

ipr-mus LD50:64 mg/kg

    PMRSDJ    Progress in Mutation Research. 1 (1981),682.

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