Tolazoline hydrochloride cas no:59-97-2

NameTolazoline hydrochloride
CAS59-97-2
Synonyms2-Benzyl-2-imidazoline hydrochloride; Tolazoline HCl; 2-BENZYL-2-IMIDAZOLINE CHLORHYDRATE
EINECS(EC#)200-447-3
Molecular FormulaC10H12N2.HCl
Molecular Weight196.67

AppearancePale yellow crystalline solid
storage temp-20°C Freezer, Under Inert Atmosphere
Sensitive Hygroscopic

Hazard Xn:Harmful;
Risk R22
Safety Hazard Codes:Xn
Risk Statements:22
22:Harmful if swallowed
Safety Statements:22
22:Do not breathe dust
RIDADR:2811

CHEMICAL IDENTIFICATION

RTECS NUMBER :

NJ2350000

CHEMICAL NAME :

2-Imidazoline, 2-benzyl-, monohydrochloride

CAS REGISTRY NUMBER :

59-97-2

LAST UPDATED :

199701

DATA ITEMS CITED :

10

MOLECULAR FORMULA :

C10-H12-N2.Cl-H

MOLECULAR WEIGHT :

196.70

WISWESSER LINE NOTATION :

T5M CN BUTJ B1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human - infant

DOSE/DURATION :

48 mg/kg/47H-C

TOXIC EFFECTS :

Gastrointestinal - ulceration or bleeding from duodenum Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :

AUPJB7 Australian Paediatric Journal. (Royal Childrens Hospital, Parkville, Vic., Australia) V.1- 1965- Volume(issue)/page/year: 22,221,1986

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human

DOSE/DURATION :

150 ug/kg

TOXIC EFFECTS :

Cardiac - change in rate Vascular - other changes Skin and Appendages - sweating

REFERENCE :

FOMDAK Folia Medica (Naples). (Naples, Italy) V.1-57, 1915-74. Volume(issue)/page/year: 27,729,1941

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,511,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

100 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,511,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

85 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,511,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

400 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay)

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1992,1971

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

130 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay)

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1992,1971

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

56700 ug/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :

JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 9,395,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5567 No. of Facilities: 41 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 2093 (estimated) No. of Female Employees: 1417 (estimated)