Safety
A deadly poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and NH3. See also CARBAMATES.
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | subcutaneous | 769ug/kg (0.769mg/kg) | behavioral: muscle contraction or spasticity) gastrointestinal: changes in structure or function of salivary glands gastrointestinal: ulceration or bleeding from large intestine | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 5, Pg. 184, 1946. |
| mouse | LD50 | intraperitoneal | 380ug/kg (0.38mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 88, 1971. | |
| mouse | LD50 | intravenous | 160ug/kg (0.16mg/kg) | International Journal of Neuropharmacology. Vol. 8, Pg. 131, 1969. | |
| mouse | LD50 | oral | 12340ug/kg (12.34mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 117, Pg. 75, 1956. | |
| mouse | LD50 | subcutaneous | 280ug/kg (0.28mg/kg) | behavioral: tremor behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: cyanosis | Journal of Pharmacy and Pharmacology. Vol. 34, Pg. 603, 1982. |
| rabbit | LD50 | intramuscular | 340ug/kg (0.34mg/kg) | Drug and Chemical Toxicology. Vol. 3, Pg. 319, 1980. | |
| rabbit | LD50 | intravenous | 250ug/kg (0.25mg/kg) | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 452, 1948. | |
| rabbit | LD50 | subcutaneous | 500ug/kg (0.5mg/kg) | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 452, 1948. | |
| rat | LD50 | intravenous | 225ug/kg (0.225mg/kg) |
peripheral nerve and sensation: flaccid paralysis without anesthesia (usually neuromuscular blockage) sense organs and special senses: chromodacyrorrea: eye lungs, thorax, or respiration: structural or functional change in trachea or bronchi
|
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 101, Pg. 205, 1955. |
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