59277-89-3|acycloguanosineProducts Supply - Chemical intermediates Network

acycloguanosine cas no:59277-89-3

Synonyms: aciclovir; Acyclovir (Patented-No Supply); N(9)-Oxyethoxymethylguanine (Acyclovir); Acyclovir; 9-[(2-Hydroxyethoxy)methyl]guanine

Identification

Nameacycloguanosine
CAS59277-89-3
Synonymsaciclovir; Acyclovir (Patented-No Supply); N(9)-Oxyethoxymethylguanine (Acyclovir); Acyclovir; 9-[(2-Hydroxyethoxy)methyl]guanine
EINECS(EC#)261-685-1
Molecular FormulaC8H11N5O3
Molecular Weight225.20464

Chemical Properties

AppearanceWhite to light yellow crystal powder
storage temp?20°C

Safety Data

Hazard Xi
Risk 36/37/38
Safety

Hazard Codes:? Irritant Xi
Risk Statements: 36/37/38?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36-26?
S22: Do not breathe dust.?
S24/25: Avoid contact with skin and eyes.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	3gm/kg/22W-I (3000mg/kg)	BLOOD: AGRANULOCYTOSIS BLOOD: THROMBOCYTOPENIA	American Journal of Emergency Medicine. Vol. 16, Pg. 396, 1998.
mammal (species unspecified)	LD50	intravenous	400mg/kg (400mg/kg)	?	Pharmacy International. Vol. 5, Pg. 191, 1984.
man	TDLo	intravenous	134ug/kg/1D-I (0.134mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Lancet. Vol. 2, Pg. 385, 1985.
man	TDLo	intravenous	107mg/kg/4D-I (107mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	American Journal of Kidney Diseases. Vol. 22, Pg. 611, 1993.
man	TDLo	oral	486mg/kg/17D- (486mg/kg)	GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION GASTROINTESTINAL: OTHER CHANGES	American Journal of Gastroenterology. Vol. 88, Pg. 2110, 1993.
mouse	LD50	intraperitoneal	724mg/kg (724mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 25, Pg. 815, 1994.
mouse	LD50	intravenous	1118mg/kg (1118mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 866, 1985.
mouse	LD50	oral	> 10gm/kg (10000mg/kg)	?	Nature. Vol. 272, Pg. 583, 1978.
mouse	LD50	subcutaneous	1118mg/kg (1118mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 866, 1985.
rat	LD50	intraperitoneal	860mg/kg (860mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 866, 1985.
rat	LD50	intravenous	750mg/kg (750mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 25, Pg. 815, 1994.
rat	LD50	oral	> 20gm/kg (20000mg/kg)	?	Drugs in Japan Vol. -, Pg. 7, 1990.
rat	LD50	subcutaneous	620mg/kg (620mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 866, 1985.
women	LDLo	multiple routes	36mg/kg/2D-I (36mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	American Journal of Kidney Diseases. Vol. 20, Pg. 647, 1992.
women	TDLo	intravenous	101mg/kg/2D-I (101mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	American Journal of Medicine. Vol. 94, Pg. 212, 1993.
women	TDLo	oral	12mg/kg/1D-I (12mg/kg)	BRAIN AND COVERINGS: MENINGEAL CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ANTIPSYCHOTIC	Southern Medical Journal. Vol. 87, Pg. 1227, 1994.
women	TDLo	oral	28mg/kg/2D-I (28mg/kg)	BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" LUNGS, THORAX, OR RESPIRATION: SPUTUM	Southern Medical Journal. Vol. 87, Pg. 1227, 1994.
women	TDLo	oral	80mg/kg/4D-I (80mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Annals of Internal Medicine. Vol. 111, Pg. 187, 1989.
women	TDLo	oral	100mg/kg/5D-I (100mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"	British Medical Journal. Vol. 289, Pg. 1424, 1984.

supplier list

Sunasia Co., Ltd.: Tel:; Address: Suite 1503, 15Fl., Huijin Mansion, No. 77 He Yi Road, Ningbo 315000 China

Apex Drug House: Tel:+91-22-22077266; Address: 28, Mahendra Mansion, Babu Genu Road,Mumbai-400 002.

Cheng Yi Pharmaceutical Co., Ltd.: Tel:; Address: 118 Hua Gong Rd , Dongping, Dongtou, Zhejing, 325700, P.R.CHINA

Hangzhou VIWA Co., Ltd.: Tel:0086-571-56836886, 56832058, 56836878; Address: Block B, 5F, Huanglong Hengli Mansion,No.5 Huanglong Road, Hangzhou, China

ChemFine International Co.,Ltd (CFI): Tel:; Address: Rm.2016, 359 Zhongshan Road, Yinchun Mansion, Wuxi,China

Hubei Teyer Pharmaceutical Co., Ltd.: Tel:86-(0)728-5342081; Address: Qiaoxiang economic development zone, Tianmen, Hubei province, China

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Synasia, Inc: Tel:+1 732-205-9880; Address: 240 Amboy Ave. Metuchen,NJ 08840

Moravek Biochemicals Inc.: Tel:+1-714-990-2018; Address: 577 Mercury Lane Brea, CA 92821 U.S.A.

Spectrum Chemical: Tel:+1-310-5168000; Address: 14422 S. San Pedro St., Gardena, CA 90248

Qilong Chemical Co., Ltd.: Tel:86-574-63858500; Address: No.586, Jiangnan Road,High-tech Park, Ningbo, Zhejiang 315040,

Praevideo LLC: Tel:+36-(1)-347-0332; Address: Baross U. 46, Budapest H 1192,

Micro Orgo Chem: Tel:+91-(22)-24448834; Address: 28, Lohar Chawl, Mahim, Mumbai, Maharashtra 400016,

Attix Corporation: Tel:+1-(416)-345-0071; Address: 120 Carlton Street, Suite 408, Toronto, Ontario M5A 4K2,

acycloguanosine cas no:59277-89-3

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