59277-89-3|acycloguanosineProducts Supply - Chemical intermediates Network

acycloguanosine cas no:59277-89-3

Synonyms: aciclovir; Acyclovir (Patented-No Supply); N(9)-Oxyethoxymethylguanine (Acyclovir); Acyclovir; 9-[(2-Hydroxyethoxy)methyl]guanine

Identification

Nameacycloguanosine
CAS59277-89-3
Synonymsaciclovir; Acyclovir (Patented-No Supply); N(9)-Oxyethoxymethylguanine (Acyclovir); Acyclovir; 9-[(2-Hydroxyethoxy)methyl]guanine
EINECS(EC#)261-685-1
Molecular FormulaC8H11N5O3
Molecular Weight225.20464

Chemical Properties

AppearanceWhite to light yellow crystal powder
storage temp?20°C

Safety Data

Hazard Xi
Risk 36/37/38
Safety

Hazard Codes:? Irritant Xi
Risk Statements: 36/37/38?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36-26?
S22: Do not breathe dust.?
S24/25: Avoid contact with skin and eyes.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	3gm/kg/22W-I (3000mg/kg)	BLOOD: AGRANULOCYTOSIS BLOOD: THROMBOCYTOPENIA	American Journal of Emergency Medicine. Vol. 16, Pg. 396, 1998.
mammal (species unspecified)	LD50	intravenous	400mg/kg (400mg/kg)	?	Pharmacy International. Vol. 5, Pg. 191, 1984.
man	TDLo	intravenous	134ug/kg/1D-I (0.134mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Lancet. Vol. 2, Pg. 385, 1985.
man	TDLo	intravenous	107mg/kg/4D-I (107mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	American Journal of Kidney Diseases. Vol. 22, Pg. 611, 1993.
man	TDLo	oral	486mg/kg/17D- (486mg/kg)	GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION GASTROINTESTINAL: OTHER CHANGES	American Journal of Gastroenterology. Vol. 88, Pg. 2110, 1993.
mouse	LD50	intraperitoneal	724mg/kg (724mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 25, Pg. 815, 1994.
mouse	LD50	intravenous	1118mg/kg (1118mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 866, 1985.
mouse	LD50	oral	> 10gm/kg (10000mg/kg)	?	Nature. Vol. 272, Pg. 583, 1978.
mouse	LD50	subcutaneous	1118mg/kg (1118mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 866, 1985.
rat	LD50	intraperitoneal	860mg/kg (860mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 866, 1985.
rat	LD50	intravenous	750mg/kg (750mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 25, Pg. 815, 1994.
rat	LD50	oral	> 20gm/kg (20000mg/kg)	?	Drugs in Japan Vol. -, Pg. 7, 1990.
rat	LD50	subcutaneous	620mg/kg (620mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 866, 1985.
women	LDLo	multiple routes	36mg/kg/2D-I (36mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	American Journal of Kidney Diseases. Vol. 20, Pg. 647, 1992.
women	TDLo	intravenous	101mg/kg/2D-I (101mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	American Journal of Medicine. Vol. 94, Pg. 212, 1993.
women	TDLo	oral	12mg/kg/1D-I (12mg/kg)	BRAIN AND COVERINGS: MENINGEAL CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ANTIPSYCHOTIC	Southern Medical Journal. Vol. 87, Pg. 1227, 1994.
women	TDLo	oral	28mg/kg/2D-I (28mg/kg)	BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" LUNGS, THORAX, OR RESPIRATION: SPUTUM	Southern Medical Journal. Vol. 87, Pg. 1227, 1994.
women	TDLo	oral	80mg/kg/4D-I (80mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Annals of Internal Medicine. Vol. 111, Pg. 187, 1989.
women	TDLo	oral	100mg/kg/5D-I (100mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"	British Medical Journal. Vol. 289, Pg. 1424, 1984.

supplier list

AerChem and Xena International LLC: Tel:812-334-9996; Address: P.O. Box 177

ZHEJIANG CHEMIALS IM & EXP CORP.: Tel:86-571-87048079; Address: No.37,Qingchun Road,Hangzhou,China

Hangzhou ICH Imp&Exp Co.,Ltd.: Tel:86-571-89939478 89939480 89939481; Address: Room 1224,Eastcom Mansion,398 Wensan Road,Hangzhou,310013 China

Beijing FortuneStar S&T Development Co., Ltd.: Tel:; Address: Zhuyuan 2-2-201, Mingliuhuayuan, Beiqijia, Changping Dist., Beijing, China

Wuhan Taiyicheng Biopharmaceutical Co., Ltd.: Tel:; Address: 7#, Meijiashan, Wuchang District, Wuhan, Hubei province, China

SHENYANG CHENGTAI FINE CHEMICALS FACTORY: Tel:+971-7-2461461; Address: RAK Air port road,RAK

Fine Chem Trading LTD: Tel:+44-079-7062-7591; Address: PO Box 292, Greenford, UB6 9ZL, England

Luna Chemicals Co.,Ltd.: Tel:; Address: 1502-1503,No.310 North Zhong Shan Rd., Hangzhou,China

Yixing Jiangshan Bio-tech Co., Ltd. (formerly Yix...: Tel:; Address: Rm.205,7# Building, XingHua XinCun,East JieFang Road, Yixing, Jiangsu, China

Welpharm Co.,Ltd: Tel:+86-21-58690818 ,58690828; Address: No. 2021 Tomson Bldg., 1 Keelung Rd., Pudong Shanghai, China

Kingland Chemicals Company Limited: Tel:+86-571-87211518,87229835; Address: Room No. 1806-1808, Jinfeng Mansion, No.281 Zhong He Zhong Road, Hangzhou, China.

Golden Harvest Fine Chemical Co., Ltd.: Tel:+86-021-65520181; Address: Rm.10C,Top Boss Bldg.,159 Handan Rd.,Shanghai .China

Shanghai Meg Imp. and Exp. Corporation: Tel:; Address: 4-101 NO.299 BISHENG RD. PUDONG, 201204 SHANGHAI, CHINA

Suntin MediPharma Co. Ltd.: Tel:+86 755 8386 5062 ; +852 2690 9351; Address: RM.2501-2502, 25/F., Convention & Exhibition Times Center, 3008 Yitian RD., Shenzhen China.

BU of APIs of Shanghai Pharmaceutical(Group)Co.,L...: Tel:; Address: 200,Taicang Road,Shanghai P.R.China

acycloguanosine cas no:59277-89-3

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