DIHYDROCODEINE BITARTRATE cas no:5965-13-9

NameDIHYDROCODEINE BITARTRATE
CAS5965-13-9
SynonymsDihydrocodeine Bitartrate [USP];Codeine, dihydro-, tartrate (1:1);DF 118;Dihydrocodeine acid tartrate;Dihydrocodeine bitartrate;NSC 117857;Paracodeine bitartrate;Tuscodin;UNII-8LXS95BSA9;4,5alpha-Epoxy-6alpha-hydroxy-3-methoxy-17-methylmorphinan hydrogen (R-(R*,R*))-tartrate;Codeine, dihydro-, tartrate (1:1) (6CI,7CI);Morphinan-6-alpha-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl-, tartrate (1:1);Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) (salt) (9CI);Morphinan-6alpha-ol, 4,5alpha-epoxy-3-methoxy-17-methyl-, tartrate (1:1) (salt) (8CI);(5alpha,6alpha)-3-methoxy-17-methyl-4,5-epoxymorphinan-6-ol
EINECS(EC#)204-732-3
Molecular FormulaC₁₈H₂₃NO₃•C₄H₆O₆
Molecular Weight451.52

Safety Poison by ingestion, intraperitoneal, subcutaneous, and parenteral routes. Human systemic effects by intravenous route: irritability. When heated to decomposition it emits toxic fumes of NOx. See also CODEINE.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

QD1729000

CAS REGISTRY NUMBER :

5965-13-9

LAST UPDATED :

199712

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C18-H23-N-O3.C4-H6-O6

MOLECULAR WEIGHT :

451.52

WISWESSER LINE NOTATION :

T B6566 B6/CO 4ABBC R BX HO PN GHT&&TTJ FQ JO1 P1 &OVYQYQVO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human

DOSE/DURATION :

357 ug/kg/5M-C

TOXIC EFFECTS :

Behavioral - irritability

REFERENCE :

LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,1425,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

359 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,42,1959

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

252 mg/kg

TOXIC EFFECTS :

Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Behavioral - analgesia

REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,333,1962

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

350 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 51,35,1934

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

142 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 66,182,1939