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5-Isobenzofurancarbonitrile,1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro- cas no:59729-33-8

Synonyms: 1-(3-Dimethylaminopropyl)-1-(4-fluorophenyl)-5-cyanophthalan;1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile;Bonitrile;Lu 10-171;Nitalapram;

Identification
Name5-Isobenzofurancarbonitrile,1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-
CAS59729-33-8
Synonyms1-(3-Dimethylaminopropyl)-1-(4-fluorophenyl)-5-cyanophthalan;1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile;Bonitrile;Lu 10-171;Nitalapram;
EINECS(EC#)261-891-1
Molecular FormulaC20H21FN2O
Molecular Weight324.391943
Chemical Properties
Appearancewhite to off-white crystalline powder
storage tempKeep tightly closed. Store at 2-8 C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard UN NO.
Safety

RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 4571ug/kg/8D- (4.571mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: HEADACHE

GASTROINTESTINAL: NAUSEA OR VOMITING
Human Psychopharmacology. Vol. 12, Pg. 119, 1997.
man LDLo oral 56mg/kg (56mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Lancet. Vol. 348, Pg. 339, 1996.
mouse LD50 intraperitoneal 179mg/kg (179mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Pharmacy and Pharmacology. Vol. 49, Pg. 1019, 1997.

supplier list

Tianjin Harmony Technology Development Co., Ltd.
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Shangyu Zhongchang Chemical Co.,LTD.
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INFA S.P.A.
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Molcan Corporation
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Fine Chem Trading LTD
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Lianyungang Guiyuan Chempharm Co.,Ltd.
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Gyma Laboratories Of America, Inc.
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Aliapharm
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Ratiopharm
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Farmamondo
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Matrix Laboratories Limited
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NTC S.r.L.
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Jiangsu Shihua Bio-Tech Co., Ltd.
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Nanjing Chemicals United Industrial Corp.
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Address: Nanjing Chemical Industry Park Luhe Nanjing Jiangsu China
Qilong Chemical Co., Ltd.
Tel:86-574-63858500
Address: No.586, Jiangnan Road,High-tech Park, Ningbo, Zhejiang 315040,

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