599-79-1|SalicylazosulfapyridineProducts Supply - Chemical intermediates Network

Salicylazosulfapyridine cas no:599-79-1

Synonyms: Benzoicacid, 2-hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]- (9CI);Salicylicacid, 5-[[p-(2-pyridylsulfamoyl)phenyl]azo]- (6CI,7CI,8CI);5-[4-(2-Pyridylsulfamyl)phenylazo]-2-hydroxybenzoic acid;5-[p-(2-Pyridylsulfamyl)phenylazo]salicylicacid;Azopyrin;Azopyrine;Azulfidine;Azulfidine EN;Benzosulfa;Colo-Pleon;NSC 203730;NSC 667219;Reupirin;Salazopyridin;Salazopyrin;Salisulf;Sulfasalazin;

Identification

NameSalicylazosulfapyridine
CAS599-79-1
SynonymsBenzoicacid, 2-hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]- (9CI);Salicylicacid, 5-[[p-(2-pyridylsulfamoyl)phenyl]azo]- (6CI,7CI,8CI);5-[4-(2-Pyridylsulfamyl)phenylazo]-2-hydroxybenzoic acid;5-[p-(2-Pyridylsulfamyl)phenylazo]salicylicacid;Azopyrin;Azopyrine;Azulfidine;Azulfidine EN;Benzosulfa;Colo-Pleon;NSC 203730;NSC 667219;Reupirin;Salazopyridin;Salazopyrin;Salisulf;Sulfasalazin;
EINECS(EC#)209-974-3
Molecular FormulaC₁₈H₁₄N₄O₅S
Molecular Weight398.39256

Chemical Properties

Appearanceyellow to brown powder
refractive index1.691
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Safety Data

Hazard Xn: Harmful;
Risk R42/43
Safety

Hazard Codes of Sulfasalazine (CAS NO.599-79-1): Harmful Xn
Risk Statements: 42/43
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 22-29/56-45
S22: Do not breathe dust.
S29: Do not empty into drains.
S56: Dispose of this material and its container at hazardous or special waste collection point.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 2
F: 8

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	3800mg/kg/19D (3800mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"	American Journal of Digestive Diseases. Vol. 23, Pg. 956, 1978.
human	TDLo	oral	429mg/kg/10D- (429mg/kg)	BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA	New England Journal of Medicine. Vol. 289, Pg. 491, 1973.
man	LDLo	oral	3200mg/kg/31D (3200mg/kg)	BLOOD: AGRANULOCYTOSIS SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" BLOOD: OTHER CHANGES	Journal of the Royal Society of Medicine. Vol. 73, Pg. 587, 1980.
man	TDLo	oral	7143ug/kg (7.143mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	New England Journal of Medicine. Vol. 306, Pg. 409, 1982.
man	TDLo	oral	143mg/kg/10D- (143mg/kg)	BLOOD: THROMBOCYTOPENIA	Annals of Internal Medicine. Vol. 102, Pg. 277, 1985.
man	TDLo	oral	357mg/kg (357mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: HEADACHE	Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 543, 1991.
man	TDLo	oral	1286mg/kg/30D (1286mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: EOSINOPHILIA BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)	Internal Medicine. Vol. 31, Pg. 108, 1992.
man	TDLo	oral	122gm/kg/8Y-I (122000mg/kg)	PERIPHERAL NERVE AND SENSATION: PARESTHESIS VASCULAR: OTHER CHANGES	Postgraduate Medical Journal. Vol. 56, Pg. 106, 1980.
man	TDLo	rectal	7143ug/kg (7.143mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	New England Journal of Medicine. Vol. 306, Pg. 409, 1982.
man	TDLo	unreported	1300mg/kg/4W- (1300mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ATAXIA	Practitioner. Vol. 204, Pg. 850, 1970.
mouse	LD50	intravenous	1096mg/kg (1096mg/kg)		Drugs in Japan Vol. -, Pg. 420, 1990.
mouse	LD50	oral	12500mg/kg (12500mg/kg)		Drugs in Japan Vol. -, Pg. 420, 1990.
mouse	LD50	subcutaneous	3gm/kg (3000mg/kg)		Drugs in Japan Vol. -, Pg. 420, 1990.
rabbit	LD50	oral	> 7500mg/kg (7500mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
rat	LD50	intravenous	1520mg/kg (1520mg/kg)		Drugs in Japan Vol. -, Pg. 420, 1990.
rat	LD50	oral	15600mg/kg (15600mg/kg)		Drugs in Japan Vol. -, Pg. 420, 1990.
rat	LD50	subcutaneous	3870mg/kg (3870mg/kg)		Drugs in Japan Vol. -, Pg. 420, 1990.
women	LDLo	unreported	840mg/kg/3W-I (840mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" IMMUNOLOGICAL INCLUDING ALLERGIC: INCREASED IMMUNE RESPONSE	Therapie. Vol. 37, Pg. 315, 1982.
women	TDLo	oral	140mg/kg/2W-I (140mg/kg)	BEHAVIORAL: HEADACHE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Lancet. Vol. 1, Pg. 917, 1984.
women	TDLo	oral	570mg/kg/11D- (570mg/kg)	BLOOD: LEUKOPENIA BLOOD: THROMBOCYTOPENIA BLOOD: OTHER CHANGES	Clinical and Experimental Dermatology. Vol. 19, Pg. 419, 1994.
women	TDLo	oral	700mg/kg/4W-I (700mg/kg)	BEHAVIORAL: EXCITEMENT LIVER: LIVER FUNCTION TESTS IMPAIRED BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT	Clinical and Experimental Rheumatology. Vol. 10, Pg. 427, 1992.
women	TDLo	unreported	2700mg/kg/13W (2700mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	British Medical Journal. Vol. 286, Pg. 1547, 1983.

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Intatrade Chemicals GmbH: Tel:49-3493-605464; Address: Bahnhofstr. 1

Salicylazosulfapyridine cas no:599-79-1

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