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Salicylazosulfapyridine cas no:599-79-1

Synonyms: Benzoicacid, 2-hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]- (9CI);Salicylicacid, 5-[[p-(2-pyridylsulfamoyl)phenyl]azo]- (6CI,7CI,8CI);5-[4-(2-Pyridylsulfamyl)phenylazo]-2-hydroxybenzoic acid;5-[p-(2-Pyridylsulfamyl)phenylazo]salicylicacid;Azopyrin;Azopyrine;Azulfidine;Azulfidine EN;Benzosulfa;Colo-Pleon;NSC 203730;NSC 667219;Reupirin;Salazopyridin;Salazopyrin;Salisulf;Sulfasalazin;

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Identification
NameSalicylazosulfapyridine
CAS599-79-1
SynonymsBenzoicacid, 2-hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]- (9CI);Salicylicacid, 5-[[p-(2-pyridylsulfamoyl)phenyl]azo]- (6CI,7CI,8CI);5-[4-(2-Pyridylsulfamyl)phenylazo]-2-hydroxybenzoic acid;5-[p-(2-Pyridylsulfamyl)phenylazo]salicylicacid;Azopyrin;Azopyrine;Azulfidine;Azulfidine EN;Benzosulfa;Colo-Pleon;NSC 203730;NSC 667219;Reupirin;Salazopyridin;Salazopyrin;Salisulf;Sulfasalazin;
EINECS(EC#)209-974-3
Molecular FormulaC18H14N4O5S
Molecular Weight398.39256
Chemical Properties
Appearanceyellow to brown powder
refractive index1.691
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Safety Data

Hazard Xn: Harmful;
Risk R42/43
Safety

Hazard Codes of Sulfasalazine (CAS NO.599-79-1): HarmfulXn
Risk Statements: 42/43 
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 22-29/56-45 
S22: Do not breathe dust. 
S29: Do not empty into drains. 
S56: Dispose of this material and its container at hazardous or special waste collection point. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 2
F: 8


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 3800mg/kg/19D (3800mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" American Journal of Digestive Diseases. Vol. 23, Pg. 956, 1978.
human TDLo oral 429mg/kg/10D- (429mg/kg) BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA New England Journal of Medicine. Vol. 289, Pg. 491, 1973.
man LDLo oral 3200mg/kg/31D (3200mg/kg) BLOOD: AGRANULOCYTOSIS

SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"

BLOOD: OTHER CHANGES		 Journal of the Royal Society of Medicine. Vol. 73, Pg. 587, 1980.
man TDLo oral 7143ug/kg (7.143mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING		 New England Journal of Medicine. Vol. 306, Pg. 409, 1982.
man TDLo oral 143mg/kg/10D- (143mg/kg) BLOOD: THROMBOCYTOPENIA Annals of Internal Medicine. Vol. 102, Pg. 277, 1985.
man TDLo oral 357mg/kg (357mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: HEADACHE		 Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 543, 1991.
man TDLo oral 1286mg/kg/30D (1286mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: EOSINOPHILIA

BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)		 Internal Medicine. Vol. 31, Pg. 108, 1992.
man TDLo oral 122gm/kg/8Y-I (122000mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS

VASCULAR: OTHER CHANGES		 Postgraduate Medical Journal. Vol. 56, Pg. 106, 1980.
man TDLo rectal 7143ug/kg (7.143mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING		 New England Journal of Medicine. Vol. 306, Pg. 409, 1982.
man TDLo unreported 1300mg/kg/4W- (1300mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ATAXIA		 Practitioner. Vol. 204, Pg. 850, 1970.
mouse LD50 intravenous 1096mg/kg (1096mg/kg)   Drugs in Japan Vol. -, Pg. 420, 1990.
mouse LD50 oral 12500mg/kg (12500mg/kg)   Drugs in Japan Vol. -, Pg. 420, 1990.
mouse LD50 subcutaneous 3gm/kg (3000mg/kg)   Drugs in Japan Vol. -, Pg. 420, 1990.
rabbit LD50 oral > 7500mg/kg (7500mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
rat LD50 intravenous 1520mg/kg (1520mg/kg)   Drugs in Japan Vol. -, Pg. 420, 1990.
rat LD50 oral 15600mg/kg (15600mg/kg)   Drugs in Japan Vol. -, Pg. 420, 1990.
rat LD50 subcutaneous 3870mg/kg (3870mg/kg)   Drugs in Japan Vol. -, Pg. 420, 1990.
women LDLo unreported 840mg/kg/3W-I (840mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

IMMUNOLOGICAL INCLUDING ALLERGIC: INCREASED IMMUNE RESPONSE		 Therapie. Vol. 37, Pg. 315, 1982.
women TDLo oral 140mg/kg/2W-I (140mg/kg) BEHAVIORAL: HEADACHE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Lancet. Vol. 1, Pg. 917, 1984.
women TDLo oral 570mg/kg/11D- (570mg/kg) BLOOD: LEUKOPENIA

BLOOD: THROMBOCYTOPENIA

BLOOD: OTHER CHANGES		 Clinical and Experimental Dermatology. Vol. 19, Pg. 419, 1994.
women TDLo oral 700mg/kg/4W-I (700mg/kg) BEHAVIORAL: EXCITEMENT

LIVER: LIVER FUNCTION TESTS IMPAIRED

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT		 Clinical and Experimental Rheumatology. Vol. 10, Pg. 427, 1992.
women TDLo unreported 2700mg/kg/13W (2700mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" British Medical Journal. Vol. 286, Pg. 1547, 1983.

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