2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,(4S,4aS,5aS,6S,12aS)- cas no:60-54-8
Synonyms: 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-(7CI,8CI);Abramycin;Achromycin;Acromicina;Actisite;Agromicina;Ambramicina;Arcanacycline;Bio-Tetra;Biocycline;Ciclibion;Cyclomycin;Deschlorobiomycin;Florocycline;Gammatet;Ibicyn;Kinciclina;Latycin;Medocycline;Mericycline;Micycline;NSC 108579;Omegamycin;Orlycycline;Panmycin;Resteclin;Retet;Robitet Robicaps;Tetra-Co;Tetra-Proter;Tetracycline;Tetralan;Tetralen;Tetramig;
Name2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,(4S,4aS,5aS,6S,12aS)-
CAS60-54-8
Synonyms2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-(7CI,8CI);Abramycin;Achromycin;Acromicina;Actisite;Agromicina;Ambramicina;Arcanacycline;Bio-Tetra;Biocycline;Ciclibion;Cyclomycin;Deschlorobiomycin;Florocycline;Gammatet;Ibicyn;Kinciclina;Latycin;Medocycline;Mericycline;Micycline;NSC 108579;Omegamycin;Orlycycline;Panmycin;Resteclin;Retet;Robitet Robicaps;Tetra-Co;Tetra-Proter;Tetracycline;Tetralan;Tetralen;Tetramig;
EINECS(EC#)200-481-9
Molecular FormulaC22H24N2O8
Molecular Weight444.43
AppearanceLight yellow crystal
refractive index1.741
storage temp2-8°C
Hazard Xn:Harmful
Risk R22
Safety
Hazard Codes of Tetracycline (CAS NO.60-54-8):?Xn,Xi
Risk Statements: 22-36/37/38?
R22: Harmful if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-36-26?
S22: Do not breathe dust.?
S36: Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: QI8750000
F: 3-8-10
Human poison by multiple routes. Experimental poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects by ingestion: somnolence, decreased motility or constipation, and urine volume decrease or anuria. Human reproductive effects by unspecified routes: effects on newborn, including postnatal measures or effects and delayed effects on newborn. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
HS Code 29413000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| guinea pig |
LD50 |
oral |
1875mg/kg (1875mg/kg) |
? |
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 109, 1982. |
| mouse |
LD50 |
intraperitoneal |
120mg/kg (120mg/kg) |
? |
"Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 134, 1967. |
| mouse |
LD50 |
intravenous |
157mg/kg (157mg/kg) |
? |
Farmaco, Edizione Scientifica. Vol. 10, Pg. 346, 1955. |
| mouse |
LD50 |
oral |
678mg/kg (678mg/kg) |
? |
American Journal of Tropical Medicine and Hygiene. Vol. 2, Pg. 254, 1953. |
| mouse |
LD50 |
subcutaneous |
400mg/kg (400mg/kg) |
? |
"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 3, Pg. 42, 1980. |
| rat |
LD50 |
intraperitoneal |
310mg/kg (310mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 493, 1982. |
| rat |
LD50 |
intravenous |
129mg/kg (129mg/kg) |
? |
Antibiotics and Chemotherapy Vol. 4, Pg. 411, 1954. |
| rat |
LD50 |
oral |
807mg/kg (807mg/kg) |
? |
Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
| women |
LDLo |
multiple routes |
310mg/kg (310mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" |
New England Journal of Medicine. Vol. 270, Pg. 157, 1964. |
| women |
TDLo |
oral |
600mg/kg/15D (600mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED |
Southern Medical Journal. Vol. 71, Pg. 961, 1978. |
