60-54-8|2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,(4S,4aS,5aS,6S,12aS)-Products Supply

2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,(4S,4aS,5aS,6S,12aS)- cas no:60-54-8

Synonyms: 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-(7CI,8CI);Abramycin;Achromycin;Acromicina;Actisite;Agromicina;Ambramicina;Arcanacycline;Bio-Tetra;Biocycline;Ciclibion;Cyclomycin;Deschlorobiomycin;Florocycline;Gammatet;Ibicyn;Kinciclina;Latycin;Medocycline;Mericycline;Micycline;NSC 108579;Omegamycin;Orlycycline;Panmycin;Resteclin;Retet;Robitet Robicaps;Tetra-Co;Tetra-Proter;Tetracycline;Tetralan;Tetralen;Tetramig;

Identification

Name2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,(4S,4aS,5aS,6S,12aS)-
CAS60-54-8
Synonyms2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-(7CI,8CI);Abramycin;Achromycin;Acromicina;Actisite;Agromicina;Ambramicina;Arcanacycline;Bio-Tetra;Biocycline;Ciclibion;Cyclomycin;Deschlorobiomycin;Florocycline;Gammatet;Ibicyn;Kinciclina;Latycin;Medocycline;Mericycline;Micycline;NSC 108579;Omegamycin;Orlycycline;Panmycin;Resteclin;Retet;Robitet Robicaps;Tetra-Co;Tetra-Proter;Tetracycline;Tetralan;Tetralen;Tetramig;
EINECS(EC#)200-481-9
Molecular FormulaC₂₂H₂₄N₂O₈
Molecular Weight444.43

Chemical Properties

AppearanceLight yellow crystal
refractive index1.741
storage temp2-8°C

Safety Data

Hazard Xn:Harmful
Risk R22
Safety

Hazard Codes of Tetracycline (CAS NO.60-54-8):?Xn,Xi
Risk Statements: 22-36/37/38?
R22: Harmful if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-36-26?
S22: Do not breathe dust.?
S36: Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: QI8750000
F: 3-8-10
Human poison by multiple routes. Experimental poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects by ingestion: somnolence, decreased motility or constipation, and urine volume decrease or anuria. Human reproductive effects by unspecified routes: effects on newborn, including postnatal measures or effects and delayed effects on newborn. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

HS Code 29413000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	1875mg/kg (1875mg/kg)	?	"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 109, 1982.
mouse	LD50	intraperitoneal	120mg/kg (120mg/kg)	?	"Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 134, 1967.
mouse	LD50	intravenous	157mg/kg (157mg/kg)	?	Farmaco, Edizione Scientifica. Vol. 10, Pg. 346, 1955.
mouse	LD50	oral	678mg/kg (678mg/kg)	?	American Journal of Tropical Medicine and Hygiene. Vol. 2, Pg. 254, 1953.
mouse	LD50	subcutaneous	400mg/kg (400mg/kg)	?	"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 3, Pg. 42, 1980.
rat	LD50	intraperitoneal	310mg/kg (310mg/kg)	?	Drugs in Japan Vol. 6, Pg. 493, 1982.
rat	LD50	intravenous	129mg/kg (129mg/kg)	?	Antibiotics and Chemotherapy Vol. 4, Pg. 411, 1954.
rat	LD50	oral	807mg/kg (807mg/kg)	?	Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
women	LDLo	multiple routes	310mg/kg (310mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"	New England Journal of Medicine. Vol. 270, Pg. 157, 1964.
women	TDLo	oral	600mg/kg/15D (600mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	Southern Medical Journal. Vol. 71, Pg. 961, 1978.

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Farmasino pharmaceuticals(Jiangsu)co.,ltd: Tel:+86-25-86907219; Address: 100 jianye road,nanjing(210004),china

KINFON PHARMACEUTICAL AND CHEMICAL CO.LTD: Tel:86-23-8650081; Address: 32F,Duhe Plaza, Lijiatuo Street, Banan Dist,Chongq

Beijing Hengrun Weiyuan Biotechnologies,. Inc.: Tel:+86-(10)-6969-6397; Address: Room A624, No.58 Liangguan Road, Fangshan District, Beijing 102000,

Applichem GmbH: Tel:+49-(6151)-93570; Address: 4, Ottoweg, Darmstadt 64291,

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Labdhi Pharmaceuticals: Tel:+91-(22)-6610 1752 / 6538 7912; Address: Unit No.7, Natalwala Terrace, 53, Gokhale Road (S),Dadar(W), Mumbai, Maharashtra 400 028,

Moon Chemical Ltd: Tel:+86-(574)-27666863; Address: Floor 21,Building 11,Xintiandi,No.689, Shiji Road, Ningbo, Zhejiang 315040,

Kerala State Drugs & Pharmaceuticals Ltd.: Tel:; Address: P.O. Box 30, Alappuzha, Alleppey, Kerala 688522,

Tablets India Ltd.: Tel:+91-(44)-4205 0000; Address: R. A. Building, 72, Marshalls Road, IV FloorChennai z, Chennai, Tamil Nadu 600008,

Trends Pharma Pvt. Ltd.: Tel:+91-(22)-26830172, 26830275; Address: 6th Floor, Matharu Arcade, Subhash Road, Vile Parle (East), Mumbai, Maharashtra 400057,

2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,(4S,4aS,5aS,6S,12aS)- cas no:60-54-8

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