60-56-0|MethimazoleProducts Supply - Chemical intermediates Network

Methimazole cas no:60-56-0

Synonyms: 4-Imidazoline-2-thione,1-methyl- (6CI,7CI);Imidazole-2-thiol, 1-methyl- (8CI);1-Methyl-1H-imidazole-2-thiol;1-Methyl-2-mercapto-1H-imidazole;1-Methyl-4-imidazoline-2-thione;1-Methylimidazole-2-thiol;1-Methylimidazole-2-thione;Basolan;Danantizol;Mercaptazole;Mercazole;Mercazolyl;

Identification

NameMethimazole
CAS60-56-0
Synonyms4-Imidazoline-2-thione,1-methyl- (6CI,7CI);Imidazole-2-thiol, 1-methyl- (8CI);1-Methyl-1H-imidazole-2-thiol;1-Methyl-2-mercapto-1H-imidazole;1-Methyl-4-imidazoline-2-thione;1-Methylimidazole-2-thiol;1-Methylimidazole-2-thione;Basolan;Danantizol;Mercaptazole;Mercazole;Mercazolyl;
EINECS(EC#)200-482-4
Molecular FormulaC₄H₆N₂S
Molecular Weight114.16

Chemical Properties

AppearanceWhite Solid
storage tempRefrigerator

Safety Data

Hazard Xn:Harmful;
Risk R43;R62;R63
Safety

Hazard Codes:?Xn
Risk Statements: 43-62-63
43: May cause sensitization by skin contact
62: Possible risk of impaired fertility
63: Possible risk of harm to the unborn child
Safety Statements: 26-27-45-36/37
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27: Take off immediately all contaminated clothing
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37: Wear suitable protective clothing and gloves
WGK Germany: 3
RTECS: NI8615000
HS Code: 29332990
Poison by subcutaneous route. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. An antithyroid drug. When heated to decomposition it emits very toxic fumes of NO_x and SO_x. See also MERCAPTANS.

HS Code 29332990

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	500mg/kg (500mg/kg)	?	National Technical Information Service. Vol. AD277-689,
mouse	LD50	oral	860mg/kg (860mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 20, 1954.
mouse	LD50	subcutaneous	345mg/kg (345mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 20, 1954.
rat	LD50	oral	2250mg/kg (2250mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 20, 1954.
rat	LD50	subcutaneous	1050mg/kg (1050mg/kg)	?	Farmaco, Edizione Scientifica. Vol. 14, Pg. 54, 1959.
women	TDLo	oral	13mg/kg/33D-I (13mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EAR BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: OTHER CHANGES	Clinical Endocrinology Vol. 51, Pg. 667, 1999.
women	TDLo	oral	492mg/kg/88W- (492mg/kg)	ENDOCRINE: CHANGE IN GONADOTROPINS BLOOD: AGRANULOCYTOSIS	Netherlands Journal of Medicine. Vol. 43, Pg. 71, 1993.

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Wuhan Dahua Weiye Pharmaceutical Co.,Ltd: Tel:86-27-59335372; Address: daijiashan 45,jiangan economic departmen zone,wuhan,hubei,China

Methimazole cas no:60-56-0

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