3-Piperidinol,5-methyl-2-[(1S)-1-[(3S,6aR,11aS,11bR)-2,3,4,6,6a,11,11a,11b-octahydro-3-hydroxy-10,11b-dimethyl-1H-benzo[a]fluoren-9-yl]ethyl]-,(2S,3R,5S)- cas no:60-70-8
Synonyms: Veratraman-3,23-diol,14,15,16,17-tetradehydro-, (3b,23b)-; Veratramine (7CI,8CI);1H-Benzo[a]fluorene, veratraman-3,23-diol deriv.; NSC 17821; NSC 23880
Name3-Piperidinol,5-methyl-2-[(1S)-1-[(3S,6aR,11aS,11bR)-2,3,4,6,6a,11,11a,11b-octahydro-3-hydroxy-10,11b-dimethyl-1H-benzo[a]fluoren-9-yl]ethyl]-,(2S,3R,5S)-
CAS60-70-8
SynonymsVeratraman-3,23-diol,14,15,16,17-tetradehydro-, (3b,23b)-; Veratramine (7CI,8CI);1H-Benzo[a]fluorene, veratraman-3,23-diol deriv.; NSC 17821; NSC 23880
Molecular FormulaC27H39 N O2
Molecular Weight409.67
refractive index1.601
storage temp-20?C Freezer
Safety
Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. When heated to decomposition Veratramine (CAS NO.60-70-8) emits toxic fumes of NOx.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intravenous |
3100ug/kg (3.1mg/kg) |
|
Cesko-Slovenska Farmacie. Vol. 2, Pg. 418, 1953.
|
| mouse |
LD50 |
subcutaneous |
4500ug/kg (4.5mg/kg) |
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 89, 1955.
|
| rabbit |
LDLo |
oral |
33mg/kg (33mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: TREMOR |
Teratology, The International Journal of Abnormal Development. Vol. 3, Pg. 175, 1970.
|
