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10H-Phenothiazine-10-ethanamine,N,N,a-trimethyl- cas no:60-87-7

Synonyms: Phenothiazine,10-[2-(dimethylamino)propyl]- (8CI);(2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine; (?à)-Promethazine;10-[2-(Dimethylamino)propyl]phenothiazine; Dimapp; Diphergan; NSC 30321;Proazamine; Procit; Prometazin; Promethazine; Protazine; Prothazin; RP 3277;Vallergine

Identification
Name10H-Phenothiazine-10-ethanamine,N,N,a-trimethyl-
CAS60-87-7
SynonymsPhenothiazine,10-[2-(dimethylamino)propyl]- (8CI);(2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine; (?à)-Promethazine;10-[2-(Dimethylamino)propyl]phenothiazine; Dimapp; Diphergan; NSC 30321;Proazamine; Procit; Prometazin; Promethazine; Protazine; Prothazin; RP 3277;Vallergine
EINECS(EC#)200-489-2
Molecular FormulaC17H20 N2 S
Molecular Weight284.45
Safety Data

Safety

Poison by ingestion, intravenous, intramuscular, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: pupillary dilation, wakefulness, hallucinations, and distorted perceptions. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A severe eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx.


Toxicity
1.    

eye-rbt 100 mg SEV

    FCTOD7    Food and Chemical Toxicology. 20 (1982),573.
2.    

eye-rbt 100 mg/4S rns MLD

    FCTOD7    Food and Chemical Toxicology. 20 (1982),573.
3.    

dni-hmn:fbr 80 nmol/L

    DNSYAG    Diseases of the Nervous System. 29 (1968),829.
4.    

otr-ham:emb 10 mg/L

    ENMUDM    Environmental Mutagenesis. 8 (Suppl 6)(1986),4.
5.    

msc-ham:lng 10 mg/L

    SHIGAZ    Shigaku. Ondotology. 70 (1983),943.
6.    

skn-cld TDLo:13 mg/kg:EYE,PSY

    CMAJAX    Canadian Medical Association Journal. 130 (1984),1460.
7.    

ipr-rat LDLo:140 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 1 (1959),156.
8.    

scu-rat LD50:700 mg/kg

    CRSBAW    Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 144 (1950),887.
9.    

ivn-rat LD50:45 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 120 (1959),450.
10.    

ims-rat LD50:169 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),185.
11. &

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