10H-Phenothiazine,10-[(1-methyl-3-piperidinyl)methyl]- cas no:60-89-9

Name10H-Phenothiazine,10-[(1-methyl-3-piperidinyl)methyl]-
CAS60-89-9
SynonymsPhenothiazine,10-[(1-methyl-3-piperidyl)methyl]- (7CI,8CI);(N-Methyl-3-piperidyl)methylphenothiazine;10-[(1-Methyl-3-piperidyl)methyl]phenothiazine;III 2318;Lacumin;MPMP;Mepazin;Mepazine;Mepazine base;Meprazine;Mesapin;Nothiazine;P 391;Pacatal;Pacatal base;Pacatol;Pakatal;Paxital;Pecatal;Pecazine
EINECS(EC#)200-490-8
Molecular FormulaC19H22 N2 S
Molecular Weight310.49

refractive index1.627

Safety Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits very toxic fumes of NOx and SOx.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

SP2625000

CHEMICAL NAME :

Phenothiazine, 10-((1-methyl-3-piperidyl)methyl)-

CAS REGISTRY NUMBER :

60-89-9

LAST UPDATED :

199707

DATA ITEMS CITED :

6

MOLECULAR FORMULA :

C19-H22-N2-S

MOLECULAR WEIGHT :

310.49

WISWESSER LINE NOTATION :

T C666 BN ISJ B1- CT6NTJ A1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 24,136,1961

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

140 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity)

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,489,1958

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

750 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CANJAE Canadian Anaesthetists' Society Journal. (Toronto, Ont., Canada) V.1-33, 1954-86. Volume(issue)/page/year: 3,224,1956

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

70 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,232,1954

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

20 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CANJAE Canadian Anaesthetists' Society Journal. (Toronto, Ont., Canada) V.1-33, 1954-86. Volume(issue)/page/year: 3,224,1956 *** REVIEWS *** TOXICOLOGY REVIEW JMSCA9 Journal of Mental Science. (London, UK) V.4-108, 1857-1962. For publisher information, see BJPYAJ. Volume(issue)/page/year: 106,755,1960