10H-Phenothiazine-10-ethanamine,N,N-diethyl- cas no:60-91-3

Name10H-Phenothiazine-10-ethanamine,N,N-diethyl-
CAS60-91-3
SynonymsPhenothiazine,10-[2-(diethylamino)ethyl]- (8CI); 10-(2-Diethylaminoethyl)phenothiazine;Diethazine; Dolisina; Eazamine; Eazaminum; Ethylemin;N-(2'-Diethylaminoethyl)dibenzoparathiazine;N-(Diethylaminoethyl)thiodiphenylamine; Parkazin; RP 2987
EINECS(EC#)200-491-3
Molecular FormulaC18H22 N2 S
Molecular Weight298.48

refractive index1.608

Safety

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	225mg/kg (225mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 171, 1954.
mouse	LD50	intravenous	56mg/kg (56mg/kg)		Helvetica Physiologia et Pharmacologica Acta. Vol. 16, Pg. 277, 1958.
mouse	LD50	oral	450mg/kg (450mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: REGIDITY	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 134, Pg. 255, 1961.
mouse	LD50	subcutaneous	450mg/kg (450mg/kg)		Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
rabbit	LD50	intravenous	20mg/kg (20mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959.
rat	LD50	intravenous	28500ug/kg (28.5mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 103, Pg. 371, 1955.