60-93-5|Quinine dihydrochlorideProducts Supply - Chemical intermediates Network

Quinine dihydrochloride cas no:60-93-5

Synonyms: Cinchonan-9-ol,6'-methoxy-, dihydrochloride, (8a,9R)- (9CI);Quinine, dihydrochloride (8CI);(-)-Quinine dihydrochloride;Acid quinine hydrochloride;Quinine bimuriate;Cinchonan-9-ol,6'-methoxy-, hydrochloride (1:2), (8a,9R)-;

Identification

NameQuinine dihydrochloride
CAS60-93-5
SynonymsCinchonan-9-ol,6'-methoxy-, dihydrochloride, (8a,9R)- (9CI);Quinine, dihydrochloride (8CI);(-)-Quinine dihydrochloride;Acid quinine hydrochloride;Quinine bimuriate;Cinchonan-9-ol,6'-methoxy-, hydrochloride (1:2), (8a,9R)-;
EINECS(EC#)200-493-4
Molecular FormulaC₂₀H₂₆Cl₂N₂O₂
Molecular Weight397.38

Chemical Properties

Appearancewhite solid

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xi: Irritant;
Risk R36/37/38
Safety

Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x and HCl. Safety Information of Quinine dihydrochloride (CAS NO.60-93-5) is:
Hazard Codes: Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 36: Wear suitable protective clothing
RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III

HS Code 29392000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	intravenous	630mg/kg/1W-I (630mg/kg)	SENSE ORGANS AND SPECIAL SENSES: "RETINAL CHANGES (PIGMENTARY DEPOSITIONS, RETINITIS, OTHER): EYE" SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE GASTROINTESTINAL: NAUSEA OR VOMITING	Japanese Journal of Ophthalmology. Vol. 28, Pg. 409, 1984.
guinea pig	LD50	intravenous	57mg/kg (57mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
guinea pig	LDLo	subcutaneous	199mg/kg (199mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 32, Pg. 595, 1935.
mouse	LD50	intravenous	86mg/kg (86mg/kg)		Biochemical Journal. Vol. 28, Pg. 426, 1934.
mouse	LD50	oral	660mg/kg (660mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rabbit	LD50	intravenous	35mg/kg (35mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rabbit	LD50	oral	641mg/kg (641mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rat	LD50	intravenous	78mg/kg (78mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rat	LD50	oral	1392mg/kg (1392mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.

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Quinine dihydrochloride cas no:60-93-5

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