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Quinine dihydrochloride cas no:60-93-5

Synonyms: Cinchonan-9-ol,6'-methoxy-, dihydrochloride, (8a,9R)- (9CI);Quinine, dihydrochloride (8CI);(-)-Quinine dihydrochloride;Acid quinine hydrochloride;Quinine bimuriate;Cinchonan-9-ol,6'-methoxy-, hydrochloride (1:2), (8a,9R)-;

Identification
NameQuinine dihydrochloride
CAS60-93-5
SynonymsCinchonan-9-ol,6'-methoxy-, dihydrochloride, (8a,9R)- (9CI);Quinine, dihydrochloride (8CI);(-)-Quinine dihydrochloride;Acid quinine hydrochloride;Quinine bimuriate;Cinchonan-9-ol,6'-methoxy-, hydrochloride (1:2), (8a,9R)-;
EINECS(EC#)200-493-4
Molecular FormulaC20H26Cl2N2O2
Molecular Weight397.38
Chemical Properties
Appearancewhite solid
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard Xi: Irritant;
Risk R36/37/38
Safety

Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Safety Information of Quinine dihydrochloride (CAS NO.60-93-5) is:
Hazard Codes: Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin 
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 36: Wear suitable protective clothing   
RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III


HS Code 29392000

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 630mg/kg/1W-I (630mg/kg) SENSE ORGANS AND SPECIAL SENSES: "RETINAL CHANGES (PIGMENTARY DEPOSITIONS, RETINITIS, OTHER): EYE"

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

GASTROINTESTINAL: NAUSEA OR VOMITING
Japanese Journal of Ophthalmology. Vol. 28, Pg. 409, 1984.
guinea pig LD50 intravenous 57mg/kg (57mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
guinea pig LDLo subcutaneous 199mg/kg (199mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 32, Pg. 595, 1935.
mouse LD50 intravenous 86mg/kg (86mg/kg)   Biochemical Journal. Vol. 28, Pg. 426, 1934.
mouse LD50 oral 660mg/kg (660mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rabbit LD50 intravenous 35mg/kg (35mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rabbit LD50 oral 641mg/kg (641mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rat LD50 intravenous 78mg/kg (78mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rat LD50 oral 1392mg/kg (1392mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.

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