60166-93-0|IopamidolProducts Supply - Chemical intermediates Network

Iopamidol cas no:60166-93-0

Synonyms: 1,3-Benzenedicarboxamide,N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-,(S)-;1,3-Benzenedicarboxamide,N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[[(2S)-2-hydroxy-1-oxopropyl]amino]-2,4,6-triiodo-(9CI);Gastromiro;Iopamidol 300;Iopamiro;Iopamiro 370;Iopamiron 300;Iopamiron 370;Isovue;Isovue 300;Isovue 370;Jopamiron 200;Niopam;Niopam 300;Oypalomin;Oypalomin 150;Solutrast;Solutrast 370;

Identification

NameIopamidol
CAS60166-93-0
Synonyms1,3-Benzenedicarboxamide,N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-,(S)-;1,3-Benzenedicarboxamide,N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[[(2S)-2-hydroxy-1-oxopropyl]amino]-2,4,6-triiodo-(9CI);Gastromiro;Iopamidol 300;Iopamiro;Iopamiro 370;Iopamiron 300;Iopamiron 370;Isovue;Isovue 300;Isovue 370;Jopamiron 200;Niopam;Niopam 300;Oypalomin;Oypalomin 150;Solutrast;Solutrast 370;
EINECS(EC#)262-093-6
Molecular FormulaC₁₇H₂₂I₃N₃O₈
Molecular Weight777.12

Chemical Properties

AppearanceWhite Crystalline Powder
alpha- 4.6°~ - 5.2°
refractive index1.738
storage temp-20?C Freezer

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	35gm/kg (35000mg/kg)	?	Farmaco, Edizione Scientifica. Vol. 32, Pg. 835, 1977.
man	TDLo	intraspinal	214uL/kg (0.214mL/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	American Journal of Emergency Medicine. Vol. 12, Pg. 329, 1994.
man	TDLo	intravenous	600mg/kg/3S-C (600mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) CARDIAC: CHANGE IN RATE	Archives of Internal Medicine. Vol. 147, Pg. 2208, 1987.
man	TDLo	intravenous	1657mg/kg (1657mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Annals of Internal Medicine. Vol. 107, Pg. 116, 1987.
mouse	LD50	intracrebral	3gm/kg (3000mg/kg)	?	Farmaco, Edizione Scientifica. Vol. 32, Pg. 835, 1977.
mouse	LD50	intraperitoneal	40825mg/kg (40825mg/kg)	?	United States Patent Document. Vol. #4001323,
mouse	LD50	intravenous	33gm/kg (33000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
mouse	LD50	oral	> 49gm/kg (49000mg/kg)	?	Drugs in Japan Vol. -, Pg. 104, 1990.
mouse	LD50	subcutaneous	> 49gm/kg (49000mg/kg)	?	Drugs in Japan Vol. -, Pg. 104, 1990.
rabbit	LD50	intravenous	20gm/kg (20000mg/kg)	?	Farmaco, Edizione Scientifica. Vol. 32, Pg. 835, 1977.
rabbit	LD50	parenteral	510mg/kg (510mg/kg)	?	United States Patent Document. Vol. #4001323,
rabbit	LD50	unreported	> 245mg/kg (245mg/kg)	?	Journal of the American College of Toxicology. Vol. 9, Pg. 563, 1990.
rat	LD	oral	> 49gm/kg (49000mg/kg)	?	Farmaco, Edizione Scientifica. Vol. 32, Pg. 835, 1977.
rat	LD50	intraarterial	13268mg/kg (13268mg/kg)	?	United States Patent Document. Vol. #4001323,
rat	LD50	intracrebral	2449mg/kg (2449mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 45, Pg. 200, 1995.
rat	LD50	intraperitoneal	35gm/kg (35000mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
rat	LD50	intravenous	22044mg/kg (22044mg/kg)	?	Acta Radiologica, Supplementum. Vol. 370, Pg. 41, 1987.
rat	LD50	subcutaneous	> 49gm/kg (49000mg/kg)	?	Drugs in Japan Vol. -, Pg. 104, 1990.
rat	LDLo	parenteral	2041mg/kg (2041mg/kg)	?	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 769, 1994.

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Iopamidol cas no:60166-93-0

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