Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)- cas no:60560-33-0

NameGuanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-
CAS60560-33-0
Synonyms(R,S)-Pinacidil;(?à)-Pinacidil; P 1134; Pinacidil;Pindac; S 1230
EINECS(EC#)262-294-9
Molecular FormulaC13H19 N5
Molecular Weight245.37

Hazard Xn
Risk 22-36/37/38
Safety

Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of NO_x and CN⁻. See also CYANIDE.
Safety Information of 2-Cyano-3-(4-pyridinyl)-1-(1,2,2-trimethylpropyl):
Hazard Codes: Xn
Risk Statements:  22-36/37/38
22:  Harmful if swallowed 
36:  Irritating to the eyes 
37:  Irritating to the respiratory system 
38:  Irritating to the skin 
Safety Statements: 36
36:  Wear suitable protective clothing

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	177mg/kg (177mg/kg)		New Cardiovascular Drugs. Vol. 3, Pg. 133, 1985.
mouse	LD50	oral	412mg/kg (412mg/kg)		New Cardiovascular Drugs. Vol. 3, Pg. 133, 1985.
rat	LD50	intravenous	155mg/kg (155mg/kg)		New Cardiovascular Drugs. Vol. 3, Pg. 133, 1985.
rat	LD50	oral	210mg/kg (210mg/kg)		New Cardiovascular Drugs. Vol. 3, Pg. 133, 1985.
rat	LD50	subcutaneous	7070mg/kg (7070mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: HEMORRHAGE BLOOD: CHANGES IN SPLEEN	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19, Pg. 2473, 1991.