7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile,4-amino-7-b-D-ribofuranosyl- cas no:606-58-6

Name7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile,4-amino-7-b-D-ribofuranosyl-
CAS606-58-6
SynonymsToyocamycin(6CI); 4-Amino-5-cyano-7-(b-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine; 7-Cyano-7-deazaadenosine;Antibiotic 1037; Antibiotic E 212; MT 1155; NSC 63701; NSC 99843; SIPI 763-1;Toyocamycin nucleoside; Toyokamycin; Unamycin B; Vengicide
Molecular FormulaC12H13 N5 O4
Molecular Weight291.30

refractive index1.849

Safety

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x and CN⁻. See also NITRILES.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	20mg/kg (20mg/kg)		"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 315, 1981.
mouse	LD50	intravenous	1500ug/kg (1.5mg/kg)		"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 318, 1981.
mouse	LD50	oral	8mg/kg (8mg/kg)		"Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 805, 1967.
mouse	LDLo	subcutaneous	10mg/kg (10mg/kg)		Journal of Antibiotics, Series A. Vol. 9, Pg. 60, 1956.