60719-84-8|amrinoneProducts Supply - Chemical intermediates Network

amrinone cas no:60719-84-8

Synonyms: -

Identification

Nameamrinone
CAS60719-84-8
Synonyms-
EINECS(EC#)262-390-0
Molecular FormulaC10H9N3O
Molecular Weight187.2

Chemical Properties

AppearanceCrystalline Solid
refractive index1.625
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard T:Toxic
Risk R25
Safety

Poison by ingestion and intravenous routes. Human systemic effects by ingestion: cardiac arrhythmias, liver function, thrombocytopenia. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x. A cardiotonic agent.
Hazard Codes:? Toxic T, Harmful Xn
Risk Statements: 25-36/37/38-20/21/22
R25 :Toxic if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 28-45-36-26
S28:After contact with skin, wash immediately with plenty of soap-suds.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36:Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DW2500000
HazardClass: 6.1(b)
PackingGroup: III

HS Code 29333999

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	3mg/kg/15M-I (3mg/kg)	BLOOD: THROMBOCYTOPENIA	Clinical Pharmacology and Therapeutics Vol. 53, Pg. 661, 1993.
dog	LDLo	intravenous	120mg/kg (120mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1117, 1990.
man	LDLo	oral	1429ug/kg (1.429mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) LIVER: LIVER FUNCTION TESTS IMPAIRED BLOOD: THROMBOCYTOPENIA	Archives of Internal Medicine. Vol. 145, Pg. 825, 1985.
mouse	LD50	intravenous	150mg/kg (150mg/kg)	?	Trends in Pharmacological Sciences. Vol. 1, Pg. 143, 1980.
mouse	LD50	oral	288mg/kg (288mg/kg)	?	Trends in Pharmacological Sciences. Vol. 1, Pg. 143, 1980.
mouse	LD50	subcutaneous	212mg/kg (212mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1111, 1990.
rabbit	LD50	oral	286mg/kg (286mg/kg)	?	Pharmazie. Vol. 41, Pg. 209, 1986.
rat	LD50	intravenous	75mg/kg (75mg/kg)	?	Pharmazie. Vol. 41, Pg. 209, 1986.
rat	LD50	oral	102mg/kg (102mg/kg)	?	New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 259, 1983.
rat	LD50	subcutaneous	150mg/kg (150mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1111, 1990.

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