| child |
TDLo |
oral |
3mg/kg/15M-I (3mg/kg) |
BLOOD: THROMBOCYTOPENIA |
Clinical Pharmacology and Therapeutics Vol. 53, Pg. 661, 1993. |
| dog |
LDLo |
intravenous |
120mg/kg (120mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS |
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1117, 1990. |
| man |
LDLo |
oral |
1429ug/kg (1.429mg/kg) |
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
LIVER: LIVER FUNCTION TESTS IMPAIRED
BLOOD: THROMBOCYTOPENIA |
Archives of Internal Medicine. Vol. 145, Pg. 825, 1985. |
| mouse |
LD50 |
intravenous |
150mg/kg (150mg/kg) |
? |
Trends in Pharmacological Sciences. Vol. 1, Pg. 143, 1980. |
| mouse |
LD50 |
oral |
288mg/kg (288mg/kg) |
? |
Trends in Pharmacological Sciences. Vol. 1, Pg. 143, 1980. |
| mouse |
LD50 |
subcutaneous |
212mg/kg (212mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1111, 1990. |
| rabbit |
LD50 |
oral |
286mg/kg (286mg/kg) |
? |
Pharmazie. Vol. 41, Pg. 209, 1986. |
| rat |
LD50 |
intravenous |
75mg/kg (75mg/kg) |
? |
Pharmazie. Vol. 41, Pg. 209, 1986. |
| rat |
LD50 |
oral |
102mg/kg (102mg/kg) |
? |
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 259, 1983. |
| rat |
LD50 |
subcutaneous |
150mg/kg (150mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1111, 1990. |
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