Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, hydrochloride (1:1) cas no:61-25-6
Synonyms: Vasal;Vasorin;Spasmo Nit;Therapav;Paveron;Ro-Papav;Pavadel;Pavagen;Pavakey;Pavased;Vasospan;1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride;6,7,3',4'-Tetramethoxy-1-benzylisoquinoline hydrochloride;6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline hydrochloride;Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, hydrochloride (9CI);Isoquinoline, 6,7-dimethoxy-1-veratryl-, hydrochloride (8CI);6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride;Papaverine hydrochloride;Papaverinium chloride;Papaversan;Paptial TR;Pavabid;Pavacap;Pavacen;Artegodan;Cardiospan;Cardoverina;Cepaverin;Cerebid;Cerespan;Dispamil;Drapavel;Dynovas;Myobid;Optenyl;Pameion;Panergon;Papavarine chlorhydrate;
NameIsoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, hydrochloride (1:1)
CAS61-25-6
SynonymsVasal;Vasorin;Spasmo Nit;Therapav;Paveron;Ro-Papav;Pavadel;Pavagen;Pavakey;Pavased;Vasospan;1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride;6,7,3',4'-Tetramethoxy-1-benzylisoquinoline hydrochloride;6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline hydrochloride;Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, hydrochloride (9CI);Isoquinoline, 6,7-dimethoxy-1-veratryl-, hydrochloride (8CI);6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride;Papaverine hydrochloride;Papaverinium chloride;Papaversan;Paptial TR;Pavabid;Pavacap;Pavacen;Artegodan;Cardiospan;Cardoverina;Cepaverin;Cerebid;Cerespan;Dispamil;Drapavel;Dynovas;Myobid;Optenyl;Pameion;Panergon;Papavarine chlorhydrate;
EINECS(EC#)200-502-1
Molecular FormulaC20H21NO4.HCl
Molecular Weight375.85
Appearancewhite rod-like crystals
storage tempAmber Vial, Refrigerator
Sensitive Light Sensitive
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Hazard Xn:Harmful
Risk R22
Safety
Poison by ingestion, intraperitoneal, intraduodenal, intravenous, and subcutaneous routes. Human systemic effects: metabolic acidosis, pulse rate increase. An experimental teratogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also PAPAVERINE.
Hazard Codes:XnCF
Risk Statements: 22-34-11
R22: Harmful if swallowed
R34: Causes burns
R11: Highly flammable
Safety Statements: 22-45-36/37/39-26-16
S22: Do not breathe dust
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S16: Keep away from sources of ignition
RIDADR: UN 1544 6.1/PG 3
WGK Germany: 1
RTECS: NW8575000
F: 8
HazardClass: 6.1
PackingGroup: III
1. |
|
cyt-ham:fbr 125 mg/L
|
|
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the National Hygiene Sciences. 96 (1978),55. |
2. |
|
cyt-ham:lng 340 mg/L
|
|
GMCRDC Gann Monograph on Cancer Research. 27 (1981),95. |
3. |
|
orl-wmn TDLo:300 mg/kg:CVS
|
|
CTOXAO Clinical Toxicology. 18 (1981),417. |
4. |
|
orl-rat LD50:360 mg/kg
|
|
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 149 (1964),200. |
5. |
|
ipr-rat LD50:64 mg/kg
|
|
ARZNAD Arzneimittel-Forschung. Drug Research. 6 (1956),454. |
6. |
|
scu-rat LD50:368 mg/kg
|
|
ARZNAD Arzneimittel-Forschung. Drug Research. 6 (1956),454. |
7. |
|
ivn-rat LD50:20 mg/kg
|
|
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 123 (1960),264. |
8. |
|
idu-rat LD50:71 mg/kg
|
|
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 180 (1969),155. |
9. |
|
orl-mus LD50:130 mg/kg
|
|
JOETD7 Journal of Ethnopharmacology. 6 (1982),127. |
10. |
|
ipr-mus LD50:108 mg/kg
|
|
JMCMAR Journal of Medicinal Chemistry. 16 (1973),1063. |
11. |
|
|