61-33-6|4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-Products Supply

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)- cas no:61-33-6

Synonyms: 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- [2S-(2a,5a,6b)]-;Penicillin G (6CI);(5R,6R)-Benzylpenicillin;Benzyl-6-aminopenicillinic acid;Benzylpenicillin;Benzylpenicillin G;Benzylpenicillinic acid;Cilloral;Cilopen;Crysticillin300 AS;Free benzylpenicillin;Free penicillin G;Gelacillin;NSC 193396;Pharmacillin;Phenylacetamidopenicillanic acid;Phenylacetyl-6-aminopenicillanic acid;Specilline G;Ursopen;

Identification

Name4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-
CAS61-33-6
Synonyms4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- [2S-(2a,5a,6b)]-;Penicillin G (6CI);(5R,6R)-Benzylpenicillin;Benzyl-6-aminopenicillinic acid;Benzylpenicillin;Benzylpenicillin G;Benzylpenicillinic acid;Cilloral;Cilopen;Crysticillin300 AS;Free benzylpenicillin;Free penicillin G;Gelacillin;NSC 193396;Pharmacillin;Phenylacetamidopenicillanic acid;Phenylacetyl-6-aminopenicillanic acid;Specilline G;Ursopen;
EINECS(EC#)200-506-3
Molecular FormulaC₁₆H₁₈N₂O₄S
Molecular Weight334.39

Chemical Properties

refractive index1.655
storage temp2-8°C

Safety Data

Hazard Xn
Risk R42/43
Safety

Poison by ingestion, intravenous, intracerebral, intraspinal, subcutaneous, and possibly other routes. Human (child) systemic effects by parenteral route: changes in cochlear (inner ear) structure or function, convulsions, and dyspnea. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x and SO_x. See other penicillin entries.
Hazard Codes of Penicillin G (CAS NO.61-33-6): Xn
Risk Statements:
42: May cause sensitization by inhalation
43: May cause sensitization by skin contact
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
28A: After contact with skin, wash immediately with plenty of water.
36: Wear suitable protective clothing
37: Wear suitable gloves

HS Code 32041900

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	parenteral	15000units/kg (15000units/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGES IN COCHLEAR STRUCTURE OR FUNCTION: EAR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Lancet. Vol. 1, Pg. 394, 1986.
dog	LD50	intracrebral	1118ug/kg (1.118mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES	Journal of Laboratory and Clinical Medicine. Vol. 34, Pg. 126, 1949.
dog	LD50	unreported	4940ug/kg (4.94mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES	Journal of Laboratory and Clinical Medicine. Vol. 34, Pg. 126, 1949.
guinea pig	LD50	unreported	38mg/kg (38mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977.
hamster	LD50	oral	24mg/kg (24mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: FOOD INTAKE (ANIMAL)	Toxicology and Applied Pharmacology. Vol. 14, Pg. 510, 1969.
hamster	LD50	subcutaneous	96mg/kg (96mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Toxicology and Applied Pharmacology. Vol. 14, Pg. 510, 1969.
mouse	LD50	intracrebral	5700ug/kg (5.7mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES	Journal of Laboratory and Clinical Medicine. Vol. 34, Pg. 126, 1949.
mouse	LD50	intraperitoneal	3500mg/kg (3500mg/kg)		Antimicrobial Agents and Chemotherapy Vol. -, Pg. 619, 1967.
mouse	LD50	intravenous	329mg/kg (329mg/kg)		Biochemical Pharmacology. Vol. 16, Pg. 1365, 1967.
mouse	LD50	oral	> 5gm/kg (5000mg/kg)		Antimicrobial Agents and Chemotherapy Vol. -, Pg. 619, 1967.
mouse	LD50	unreported	7800mg/kg (7800mg/kg)		Antibiotiki. Vol. 23, Pg. 317, 1978.
rabbit	LD50	intracrebral	653ug/kg (0.653mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES	Journal of Laboratory and Clinical Medicine. Vol. 34, Pg. 126, 1949.
rat	LD50	oral	8gm/kg (8000mg/kg)		Antibiotics and Chemotherapy Vol. 12, Pg. 249, 1962.
rat	LD50	unreported	9gm/kg (9000mg/kg)		Antibiotiki. Vol. 23, Pg. 317, 1978.

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4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)- cas no:61-33-6

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