| cat |
LD50 |
intravenous |
100mg/kg (100mg/kg) |
? |
Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976. |
| man |
TDLo |
oral |
14285ug/kg/3D (14.285mg/kg) |
? |
British Journal of Clinical Practice. Vol. 49, Pg. 161, 1995. |
| man |
TDLo |
oral |
14285ug/kg/3D (14.285mg/kg) |
? |
British Journal of Clinical Practice. Vol. 49, Pg. 161, 1995. |
| man |
TDLo |
oral |
257mg/kg/12D- (257mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
British Medical Journal. Vol. 291, Pg. 661, 1985. |
| man |
TDLo |
oral |
840mg/kg/6W-I (840mg/kg) |
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
British Medical Journal. Vol. 287, Pg. 1626, 1983. |
| mouse |
LD50 |
intramuscular |
400mg/kg (400mg/kg) |
? |
Pharmaceutical Chemistry Journal Vol. 17, Pg. 353, 1983. |
| mouse |
LD50 |
intraperitoneal |
120mg/kg (120mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 36, 1969. |
| mouse |
LD50 |
intravenous |
96mg/kg (96mg/kg) |
? |
Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 1392, 1969. |
| mouse |
LD50 |
oral |
525mg/kg (525mg/kg) |
? |
Journal de Pharmacologie. Vol. 2, Pg. 259, 1971. |
| mouse |
LDLo |
subcutaneous |
> 2gm/kg (2000mg/kg) |
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1579, 1970. |
| rat |
LD50 |
intraperitoneal |
327mg/kg (327mg/kg) |
? |
Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
| rat |
LD50 |
intravenous |
112mg/kg (112mg/kg) |
? |
Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976. |
| rat |
LD50 |
oral |
740mg/kg (740mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 28, Pg. 99, 1981. |
| women |
LDLo |
oral |
280mg/kg/2W-I (280mg/kg) |
LIVER: LIVER FUNCTION TESTS IMPAIRED
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA |
Drug Safety. Vol. 6, Pg. 230, 1991. |
| women |
TDLo |
oral |
20mg/kg/4D-I (20mg/kg) |
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS |
Canadian Medical Association Journal. Vol. 126, Pg. 894, 1982. |
| women |
TDLo |
oral |
450mg/kg (450mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
BEHAVIORAL: TOXIC PSYCHOSIS
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
South African Medical Journal. Vol. 67, Pg. 823, 1985. |
| women |
TDLo |
unreported |
120mg/kg/4D (120mg/kg) |
BEHAVIORAL: WITHDRAWAL
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Lancet. Vol. 2, Pg. 745, 1980. |
