Phenothiazin-5-ium,3,7-bis(dimethylamino)-, chloride (1:1) cas no:61-73-4

NamePhenothiazin-5-ium,3,7-bis(dimethylamino)-, chloride (1:1)
CAS61-73-4
SynonymsC.I. BasicBlue 9 (6CI,8CI);Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride (9CI);Basic Blue 9;C.I. Solvent Blue 8;Calcozine Blue ZF;Izit Crystal Dye;Leather Pure Blue HB;Methylene Blue 2B;Methylene Blue 2BN;Methylene Blue2BP;Methylene Blue A;Methylene Blue BB;Methylene Blue BP;Methylene Blue BPC;Methylene Blue BX;Methylene Blue FZ;Methylene Blue G;MethyleneBlue SG;Methylene Blue SP;Methylene Blue ZF;Methylene Blue ZX;Methylene bluepolychrome;NSC 617593;Sandocryl Blue BRL;Schultz 1038;Solvent Blue 8;Tetramethylthioninechloride;Urolene Blue;Virostat;Yamamoto Methylene Blue B;Yamamoto MethyleneBlue ZF;
EINECS(EC#)200-515-2
Molecular FormulaC₁₆H₁₈ClN₃S
Molecular Weight319.85222

Appearancegreen fine crystalline powder
storage tempStore at RT

Hazard Xn:Harmful
Risk R22;R41
Safety Hazard Codes:Xn
Risk Statements:10-41-22-20/21/22
10:Flammable
41:Risk of serious damage to eyes
22:Harmful if swallowed
20/21/22:Harmful by inhalation, in contact with skin and if swallowed
Safety Statements:26-39-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
39:Wear eye/face protection
36:Wear suitable protective clothing
RIDADR:UN 1993 3/PG 3
WGK Germany:3

CHEMICAL IDENTIFICATION

RTECS NUMBER :

SO5600000

CHEMICAL NAME :

3H-Phenothiazine, 7-(dimethylamino)-3-(methylimino)-, 3-methochloride

CAS REGISTRY NUMBER :

61-73-4

LAST UPDATED :

199710

DATA ITEMS CITED :

36

MOLECULAR FORMULA :

C16-H18-N3-S.Cl

MOLECULAR WEIGHT :

319.88

WISWESSER LINE NOTATION :

T C666 BS EY INJ EUK1&1 MN1&1 &G &421

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Human - infant

DOSE/DURATION :

15 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - cyanosis Blood - other changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1180 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

180 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

190 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1250 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

3500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

150 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

77 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

50 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

10 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

41 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - domestic

DOSE/DURATION :

42300 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2500 mg/kg

SEX/DURATION :

female 1-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :

DNA adduct

TEST SYSTEM :

Mammal - species unspecified Lymphocyte

DOSE/DURATION :

1830 nmol/L

REFERENCE :

BIPMAA Biopolymers. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1963- Volume(issue)/page/year: 12,1099,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1469 No. of Facilities: 4471 (estimated) No. of Industries: 35 No. of Occupations: 34 No. of Employees: 25916 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1406 No. of Facilities: 150 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 664 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1469 No. of Facilities: 5956 (estimated) No. of Industries: 29 No. of Occupations: 51 No. of Employees: 74208 (estimated) No. of Female Employees: 43305 (estimated)